TY - JOUR
T1 - A Case-Only Genome-Wide Interaction Study of Smoking and Bladder Cancer Risk
T2 - Results from the COBLAnCE Cohort
AU - Karimi, Maryam
AU - Mendez-Pineda, Sebastian
AU - Blanché, Hélène
AU - Boland, Anne
AU - Besse, Céline
AU - Deleuze, Jean François
AU - Meng, Xiang Yu
AU - Sirab, Nanor
AU - Groussard, Karine
AU - Lebret, Thierry
AU - Bonastre, Julia
AU - Allory, Yves
AU - Radvanyi, François
AU - Benhamou, Simone
AU - Michiels, Stefan
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Bladder cancer (BC) is the 6th most common cancer worldwide, with tobacco smoking considered as its main risk factor. Accumulating evidence has found associations between genetic variants and the risk of BC. Candidate gene-environment interaction studies have suggested interactions between cigarette smoking and NAT2/GSTM1 gene variants. Our objective was to perform a genome-wide association case-only study using the French national prospective COBLAnCE cohort (COhort to study BLAdder CancEr), focusing on smoking behavior. The COBLAnCE cohort comprises 1800 BC patients enrolled between 2012 and 2018. Peripheral blood samples collected at enrolment were genotyped using the Illumina Global Screening Array with a Multi-Disease drop-in panel. Genotyping data (9,719,614 single nucleotide polymorphisms (SNP)) of 1674, 1283, and 1342 patients were analyzed for smoking status, average tobacco consumption, and age at smoking initiation, respectively. A genome-wide association study (GWAS) was conducted adjusting for gender, age, and genetic principal components. The results suggest new candidate loci (4q22.1, 12p13.1, 16p13.3) interacting with smoking behavior for the risk of BC. Our results need to be validated in other case-control or cohort studies.
AB - Bladder cancer (BC) is the 6th most common cancer worldwide, with tobacco smoking considered as its main risk factor. Accumulating evidence has found associations between genetic variants and the risk of BC. Candidate gene-environment interaction studies have suggested interactions between cigarette smoking and NAT2/GSTM1 gene variants. Our objective was to perform a genome-wide association case-only study using the French national prospective COBLAnCE cohort (COhort to study BLAdder CancEr), focusing on smoking behavior. The COBLAnCE cohort comprises 1800 BC patients enrolled between 2012 and 2018. Peripheral blood samples collected at enrolment were genotyped using the Illumina Global Screening Array with a Multi-Disease drop-in panel. Genotyping data (9,719,614 single nucleotide polymorphisms (SNP)) of 1674, 1283, and 1342 patients were analyzed for smoking status, average tobacco consumption, and age at smoking initiation, respectively. A genome-wide association study (GWAS) was conducted adjusting for gender, age, and genetic principal components. The results suggest new candidate loci (4q22.1, 12p13.1, 16p13.3) interacting with smoking behavior for the risk of BC. Our results need to be validated in other case-control or cohort studies.
KW - bladder cancer
KW - case-only design
KW - genome-wide association study
KW - smoking
UR - http://www.scopus.com/inward/record.url?scp=85170214950&partnerID=8YFLogxK
U2 - 10.3390/cancers15174218
DO - 10.3390/cancers15174218
M3 - Article
AN - SCOPUS:85170214950
SN - 2072-6694
VL - 15
JO - Cancers
JF - Cancers
IS - 17
M1 - 4218
ER -