Résumé
Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10 -10). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 × 10 -9), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10 -9). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations.
langue originale | Anglais |
---|---|
Pages (de - à) | 1210-1214 |
Nombre de pages | 5 |
journal | Nature Genetics |
Volume | 43 |
Numéro de publication | 12 |
Les DOIs | |
état | Publié - 1 déc. 2011 |
Modification externe | Oui |
Contient cette citation
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
Dans: Nature Genetics, Vol 43, Numéro 12, 01.12.2011, p. 1210-1214.
Résultats de recherche: Contribution à un journal › Article › Revue par des pairs
TY - JOUR
T1 - A common variant at the TERT-CLPTM1L locus is associated with estrogen receptorĝ€"negative breast cancer
AU - Haiman, Christopher A.
AU - Chen, Gary K.
AU - Vachon, Celine M.
AU - Canzian, Federico
AU - Dunning, Alison
AU - Millikan, Robert C.
AU - Wang, Xianshu
AU - Ademuyiwa, Foluso
AU - Ahmed, Shahana
AU - Ambrosone, Christine B.
AU - Baglietto, Laura
AU - Balleine, Rosemary
AU - Bandera, Elisa V.
AU - Beckmann, Matthias W.
AU - Berg, Christine D.
AU - Bernstein, Leslie
AU - Blomqvist, Carl
AU - Blot, William J.
AU - Brauch, Hiltrud
AU - Buring, Julie E.
AU - Carey, Lisa A.
AU - Carpenter, Jane E.
AU - Chang-Claude, Jenny
AU - Chanock, Stephen J.
AU - Chasman, Daniel I.
AU - Clarke, Christine L.
AU - Cox, Angela
AU - Cross, Simon S.
AU - Deming, Sandra L.
AU - Diasio, Robert B.
AU - Dimopoulos, Athanasios M.
AU - Driver, W. Ryan
AU - Dünnebier, Thomas
AU - Durcan, Lorraine
AU - Eccles, Diana
AU - Edlund, Christopher K.
AU - Ekici, Arif B.
AU - Fasching, Peter A.
AU - Feigelson, Heather S.
AU - Flesch-Janys, Dieter
AU - Fostira, Florentia
AU - Försti, Asta
AU - Fountzilas, George
AU - Gerty, Susan M.
AU - Giles, Graham G.
AU - Godwin, Andrew K.
AU - Goodfellow, Paul
AU - Graham, Nikki
AU - Greco, Dario
AU - Hamann, Ute
AU - Hankinson, Susan E.
AU - Hartmann, Arndt
AU - Hein, Rebecca
AU - Heinz, Judith
AU - Holbrook, Andrea
AU - Hoover, Robert N.
AU - Hu, Jennifer J.
AU - Hunter, David J.
AU - Ingles, Sue A.
AU - Irwanto, Astrid
AU - Ivanovich, Jennifer
AU - John, Esther M.
AU - Johnson, Nicola
AU - Jukkola-Vuorinen, Arja
AU - Kaaks, Rudolf
AU - Ko, Yon Dschun
AU - Kolonel, Laurence N.
AU - Konstantopoulou, Irene
AU - Kosma, Veli Matti
AU - Kulkarni, Swati
AU - Lambrechts, Diether
AU - Lee, Adam M.
AU - Marchand, Loïc Le
AU - Lesnick, Timothy
AU - Liu, Jianjun
AU - Lindstrom, Sara
AU - Mannermaa, Arto
AU - Margolin, Sara
AU - Martin, Nicholas G.
AU - Miron, Penelope
AU - Montgomery, Grant W.
AU - Nevanlinna, Heli
AU - Nickels, Stephan
AU - Nyante, Sarah
AU - Olswold, Curtis
AU - Palmer, Julie
AU - Pathak, Harsh
AU - Pectasides, Dimitrios
AU - Perou, Charles M.
AU - Peto, Julian
AU - Pharoah, Paul D.P.
AU - Pooler, Loreall C.
AU - Press, Michael F.
AU - Pylkäs, Katri
AU - Rebbeck, Timothy R.
AU - Rodriguez-Gil, Jorge L.
AU - Rosenberg, Lynn
AU - Ross, Eric
AU - Rüdiger, Thomas
AU - Silva, Isabel Dos Santos
AU - Sawyer, Elinor
AU - Schmidt, Marjanka K.
AU - Schulz-Wendtland, Rüdiger
AU - Schumacher, Fredrick
AU - Severi, Gianluca
AU - Sheng, Xin
AU - Signorello, Lisa B.
AU - Sinn, Hans Peter
AU - Stevens, Kristen N.
AU - Southey, Melissa C.
AU - Tapper, William J.
AU - Tomlinson, Ian
AU - Hogervorst, Frans B.L.
AU - Wauters, Els
AU - Weaver, Joellen
AU - Wildiers, Hans
AU - Winqvist, Robert
AU - Berg, David Van Den
AU - Wan, Peggy
AU - Xia, Lucy Y.
AU - Yannoukakos, Drakoulis
AU - Zheng, Wei
AU - Ziegler, Regina G.
AU - Siddiq, Afshan
AU - Slager, Susan L.
AU - Stram, Daniel O.
AU - Easton, Douglas
AU - Kraft, Peter
AU - Henderson, Brian E.
AU - Couch, Fergus J.
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10 -10). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 × 10 -9), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10 -9). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations.
AB - Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls of European ancestry. We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10 -10). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 × 10 -9), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10 -9). Our results identify a genetic locus associated with estrogen receptor negative breast cancer subtypes in multiple populations.
UR - http://www.scopus.com/inward/record.url?scp=82255183150&partnerID=8YFLogxK
U2 - 10.1038/ng.985
DO - 10.1038/ng.985
M3 - Article
C2 - 22037553
AN - SCOPUS:82255183150
SN - 1061-4036
VL - 43
SP - 1210
EP - 1214
JO - Nature Genetics
JF - Nature Genetics
IS - 12
ER -