A Comprehensive Review on the Role of Lurbinectedin in Soft Tissue Sarcomas

Rita Khoury, Tarek Assi, Rebecca Ibrahim, Tony Ibrahim, Benjamin Verret, Clemence Henon, Ratislav Bahleda, Axel Le Cesne

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    Résumé

    Soft tissue sarcoma (STS), a substantial group of aggressive and rare tumors with tissue heterogeneity, is infrequently represented in clinical trials with an urgent necessity for newer treatment options. Lurbinectedin, an analog of trabectedin, is currently approved, in various countries, as a single agent, for the treatment of patients with relapsed small cell lung cancer (SCLC). However, preclinical and phase I and phase II trials have demonstrated the efficacy of lurbinectedin in different tumor types, including STS. The better understanding of the pathophysiology and evolution of STS as well as the mechanism of action of lurbinectedin in addition to the available data regarding the activity of this drug in this subset of patients will pave the way to newer therapeutic options and strategies.

    langue originaleAnglais
    Pages (de - à)176-190
    Nombre de pages15
    journalCurrent Treatment Options in Oncology
    Volume25
    Numéro de publication2
    Les DOIs
    étatPublié - 1 févr. 2024

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