A mouse plasma peptide atlas as a resource for disease proteomics

Qing Zhang, Rajasree Menon, Eric W. Deutsch, Sharon J. Pitteri, Vitor M. Faca, Hong Wang, Lisa F. Newcomb, Ronald A. DePinho, Nabeel Bardeesy, Daniela Dinulescu, Kenneth E. Hung, Raju Kucherlapati, Tyler Jacks, Katerina Politi, Ruedi Aebersold, Gilbert S. Omenn, David J. States, Samir M. Hanash

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

20 Citations (Scopus)

Résumé

We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis.

langue originaleAnglais
Numéro d'articleR93
journalGenome biology
Volume9
Numéro de publication6
Les DOIs
étatPublié - 3 juin 2008
Modification externeOui

Contient cette citation