A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia

O. A. Bernard; M. Busson-LeConiat; P. Ballerini; M. Mauchauffé; V. Della Valle; R. Monni; F. Nguyen Khac; T. Mercher; V. Penard-Lacronique; P. Pasturaud; L. Gressin; R. Heilig; M. T. Daniel; M. Lessard; R. Berger

doi:10.1038/sj.leu.2402249

A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia

O. A. Bernard, M. Busson-LeConiat, P. Ballerini, M. Mauchauffé, V. Della Valle, R. Monni, F. Nguyen Khac, T. Mercher, V. Penard-Lacronique, P. Pasturaud, L. Gressin, R. Heilig, M. T. Daniel, M. Lessard, R. Berger

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Résumé

FISH identified a cryptic t(5;14)(q35;q32) in T acute lymphoblastic leukemia (ALL), whereas it was not observed in B ALL samples. This translocation is present in five out of 23 (22%) children and adolescents with T ALL tested. RanBP17, a gene coding for a member of the importin β protein family, and Hox11Like2, an orphan homeobox gene were mapped close to the chromosome 5 breakpoints and CTIP2, which is highly expressed during normal T cell differentiation, was localized in the vicinity of the chromosome 14 breakpoints. The Hox11L2 gene was found to be transcriptionally activated as a result of the translocation, probably under the influence of CTIP2 transcriptional regulation elements. These data establish the t(5;14)(q35;q32) as a major abnormality, and Hox11 family member activation as an important pathway in T ALL leukemogenesis.

langue originale	Anglais
Pages (de - à)	1495-1504
Nombre de pages	10
journal	Leukemia
Volume	15
Numéro de publication	10
Les DOIs	https://doi.org/10.1038/sj.leu.2402249
état	Publié - 1 janv. 2001
Modification externe	Oui

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10.1038/sj.leu.2402249

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Bernard, O. A., Busson-LeConiat, M., Ballerini, P., Mauchauffé, M., Della Valle, V., Monni, R., Khac, F. N., Mercher, T., Penard-Lacronique, V., Pasturaud, P., Gressin, L., Heilig, R., Daniel, M. T., Lessard, M., & Berger, R. (2001). A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia. Leukemia, 15(10), 1495-1504. https://doi.org/10.1038/sj.leu.2402249

@article{f8dfb5eb1b50454c9065c69ede2a3d75,

title = "A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia",

abstract = "FISH identified a cryptic t(5;14)(q35;q32) in T acute lymphoblastic leukemia (ALL), whereas it was not observed in B ALL samples. This translocation is present in five out of 23 (22%) children and adolescents with T ALL tested. RanBP17, a gene coding for a member of the importin β protein family, and Hox11Like2, an orphan homeobox gene were mapped close to the chromosome 5 breakpoints and CTIP2, which is highly expressed during normal T cell differentiation, was localized in the vicinity of the chromosome 14 breakpoints. The Hox11L2 gene was found to be transcriptionally activated as a result of the translocation, probably under the influence of CTIP2 transcriptional regulation elements. These data establish the t(5;14)(q35;q32) as a major abnormality, and Hox11 family member activation as an important pathway in T ALL leukemogenesis.",

keywords = "CTIP2, FISH, Hox11L2, T ALL, t(5;14)",

author = "Bernard, {O. A.} and M. Busson-LeConiat and P. Ballerini and M. Mauchauff{\'e} and {Della Valle}, V. and R. Monni and Khac, {F. Nguyen} and T. Mercher and V. Penard-Lacronique and P. Pasturaud and L. Gressin and R. Heilig and Daniel, {M. T.} and M. Lessard and R. Berger",

note = "Funding Information: This work was supported by INSERM and the Ligue Nationale Contre le Cancer. Thomas Mercher and Richard Monni are recipients of fellowships from the Minist{\`e}re de l{\textquoteright}Education Nationale. Florence Nguyen Khac is supported by the Acad{\'e}-mie Nationale de M{\'e}decine. We thank W Vainschenker for providing us with the M70E cell line.",

year = "2001",

month = jan,

day = "1",

doi = "10.1038/sj.leu.2402249",

language = "English",

volume = "15",

pages = "1495--1504",

journal = "Leukemia",

issn = "0887-6924",

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Bernard, OA, Busson-LeConiat, M, Ballerini, P, Mauchauffé, M, Della Valle, V, Monni, R, Khac, FN, Mercher, T, Penard-Lacronique, V, Pasturaud, P, Gressin, L, Heilig, R, Daniel, MT, Lessard, M & Berger, R 2001, 'A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia', Leukemia, VOL. 15, Numéro 10, p. 1495-1504. https://doi.org/10.1038/sj.leu.2402249

TY - JOUR

T1 - A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia

AU - Bernard, O. A.

AU - Busson-LeConiat, M.

AU - Ballerini, P.

AU - Mauchauffé, M.

AU - Della Valle, V.

AU - Monni, R.

AU - Khac, F. Nguyen

AU - Mercher, T.

AU - Penard-Lacronique, V.

AU - Pasturaud, P.

AU - Gressin, L.

AU - Heilig, R.

AU - Daniel, M. T.

AU - Lessard, M.

AU - Berger, R.

N1 - Funding Information: This work was supported by INSERM and the Ligue Nationale Contre le Cancer. Thomas Mercher and Richard Monni are recipients of fellowships from the Ministère de l’Education Nationale. Florence Nguyen Khac is supported by the Acadé-mie Nationale de Médecine. We thank W Vainschenker for providing us with the M70E cell line.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - FISH identified a cryptic t(5;14)(q35;q32) in T acute lymphoblastic leukemia (ALL), whereas it was not observed in B ALL samples. This translocation is present in five out of 23 (22%) children and adolescents with T ALL tested. RanBP17, a gene coding for a member of the importin β protein family, and Hox11Like2, an orphan homeobox gene were mapped close to the chromosome 5 breakpoints and CTIP2, which is highly expressed during normal T cell differentiation, was localized in the vicinity of the chromosome 14 breakpoints. The Hox11L2 gene was found to be transcriptionally activated as a result of the translocation, probably under the influence of CTIP2 transcriptional regulation elements. These data establish the t(5;14)(q35;q32) as a major abnormality, and Hox11 family member activation as an important pathway in T ALL leukemogenesis.

AB - FISH identified a cryptic t(5;14)(q35;q32) in T acute lymphoblastic leukemia (ALL), whereas it was not observed in B ALL samples. This translocation is present in five out of 23 (22%) children and adolescents with T ALL tested. RanBP17, a gene coding for a member of the importin β protein family, and Hox11Like2, an orphan homeobox gene were mapped close to the chromosome 5 breakpoints and CTIP2, which is highly expressed during normal T cell differentiation, was localized in the vicinity of the chromosome 14 breakpoints. The Hox11L2 gene was found to be transcriptionally activated as a result of the translocation, probably under the influence of CTIP2 transcriptional regulation elements. These data establish the t(5;14)(q35;q32) as a major abnormality, and Hox11 family member activation as an important pathway in T ALL leukemogenesis.

KW - CTIP2

KW - FISH

KW - Hox11L2

KW - T ALL

KW - t(5;14)

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U2 - 10.1038/sj.leu.2402249

DO - 10.1038/sj.leu.2402249

M3 - Article

C2 - 11587205

AN - SCOPUS:0034781537

SN - 0887-6924

VL - 15

SP - 1495

EP - 1504

JO - Leukemia

JF - Leukemia

IS - 10

ER -