A new score based on biomarker values to predict the prognosis of locally advanced cervical cancer

Amandine Maulard, Cyrus Chargari, Matthieu Faron, Asim Alwohaibi, Alexandra Leary, Patricia Pautier, Catherine Genestie, Philippe Morice, Sebastien Gouy

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    5 Citations (Scopus)

    Résumé

    Objective: To define a prognostic score based on pretreatment values of leucocyte, platelet and hemoglobin in locally advanced cervical cancer (LACC). Material and methods: We conducted a prospective study of 238 patients for LACC with negative PET imaging in the para-aortic (PA) area and who were undergoing laparoscopic PA lymphadenectomies. All patients were treated with chemo-radiation and brachytherapy. Results: Patients had clinical International Federation of Gynecology and Obstetrics stages IB2 (n = 76), IIA (n = 13), IIB (n = 122), III (n = 18) or IVA (n = 9). We identified three biological parameters (at the time of diagnosis) with three cut-offs which impacted disease free survival (DFS) and overall survival (OS): <12 g/dL for hemoglobin, >10,000/μL for leucocyte and >300 × 109/L for platelet. A score is calculated, as shown in the table below, by adding the scores of all three biological parameters together (with a maximum score of three). [Table presented] DFS at 36 months was 87.3% [78.3–97.4], 58% [45–74.6], 79.1% [71.1–88], 58% [45–74.6] and 56.8% [37.8–85.4] for scores of 0, 1, 2 and 3 respectively. OS at 36 months was 92.6% [84.9–100], 84% [76.6–92.1], 62.5% [48.9–79.9] and 67% [46.8–96] for scores of 0, 1, 2 and 3 respectively. Conclusion: This score includes three biomarkers with easily remembered cut-offs that allow us to identify, at the time of diagnosis, those patients with a high risk of relapse (scores of two or three) and those requiring dose escalation.

    langue originaleAnglais
    Pages (de - à)534-538
    Nombre de pages5
    journalGynecologic Oncology
    Volume159
    Numéro de publication2
    Les DOIs
    étatPublié - 1 nov. 2020

    Contient cette citation