A novel dendritic cell subset involved in tumor immunosurveillance

Julien Taieb; Nathalie Chaput; Cédric Ménard; Lionel Apetoh; Evelyn Ullrich; Mathieu Bonmort; Marie Péquignot; Noelia Casares; Magali Terme; Caroline Flament; Paule Opolon; Yann Lecluse; Didier Métivier; Elena Tomasello; Eric Vivier; François Ghiringhelli; François Martin; David Klatzmann; Thierry Poynard; Thomas Tursz; Graça Raposo; Hideo Yagita; Bernard Ryffel; Guido Kroemer; Laurence Zitvogel

doi:10.1038/nm1356

A novel dendritic cell subset involved in tumor immunosurveillance

Julien Taieb, Nathalie Chaput, Cédric Ménard, Lionel Apetoh, Evelyn Ullrich, Mathieu Bonmort, Marie Péquignot, Noelia Casares, Magali Terme, Caroline Flament, Paule Opolon, Yann Lecluse, Didier Métivier, Elena Tomasello, Eric Vivier, François Ghiringhelli, François Martin, David Klatzmann, Thierry Poynard, Thomas TurszGraça Raposo, Hideo Yagita, Bernard Ryffel, Guido Kroemer, Laurence Zitvogel

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

367 Citations (Scopus)

Résumé

The interferon (IFN)-γ-induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice ^1,2. Here we show that the main source of IFN-γ is not the conventional NK cell but a subset of B220⁺Ly6C^- dendritic cells, which are atypical insofar as they express NK cell-surface molecules. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220⁺NK1.1⁺ dendritic cells secrete high levels of IFN-γ and mediate TRAIL-dependent lysis of tumor cells. Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2^-/-II2rg^-/- mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not. In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response.

langue originale	Anglais
Pages (de - à)	214-219
Nombre de pages	6
journal	Nature Medicine
Volume	12
Numéro de publication	2
Les DOIs	https://doi.org/10.1038/nm1356
état	Publié - 14 mars 2006

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10.1038/nm1356

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Taieb, J., Chaput, N., Ménard, C., Apetoh, L., Ullrich, E., Bonmort, M., Péquignot, M., Casares, N., Terme, M., Flament, C., Opolon, P., Lecluse, Y., Métivier, D., Tomasello, E., Vivier, E., Ghiringhelli, F., Martin, F., Klatzmann, D., Poynard, T., ... Zitvogel, L. (2006). A novel dendritic cell subset involved in tumor immunosurveillance. Nature Medicine, 12(2), 214-219. https://doi.org/10.1038/nm1356

@article{906f1abe7da44108af6a08597539e36b,

title = "A novel dendritic cell subset involved in tumor immunosurveillance",

abstract = "The interferon (IFN)-γ-induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice 1,2. Here we show that the main source of IFN-γ is not the conventional NK cell but a subset of B220+Ly6C- dendritic cells, which are atypical insofar as they express NK cell-surface molecules. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220+NK1.1+ dendritic cells secrete high levels of IFN-γ and mediate TRAIL-dependent lysis of tumor cells. Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2-/-II2rg-/- mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not. In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response.",

author = "Julien Taieb and Nathalie Chaput and C{\'e}dric M{\'e}nard and Lionel Apetoh and Evelyn Ullrich and Mathieu Bonmort and Marie P{\'e}quignot and Noelia Casares and Magali Terme and Caroline Flament and Paule Opolon and Yann Lecluse and Didier M{\'e}tivier and Elena Tomasello and Eric Vivier and Fran{\c c}ois Ghiringhelli and Fran{\c c}ois Martin and David Klatzmann and Thierry Poynard and Thomas Tursz and Gra{\c c}a Raposo and Hideo Yagita and Bernard Ryffel and Guido Kroemer and Laurence Zitvogel",

note = "Funding Information: We thank F. Housseau for communicating his data on IKDCs and providing reagents, J. Tschopp (University of Lausanne) and G. Salvesen (Burnham Institute) for providing plasmids and M.L. Albert (Pasteur Institute) for providing reagents. J. Taieb is supported by a Poste d{\textquoteright}accueil INSERM and AP-HP, and N. Chaput is supported by a European fellowship (QLRT-2001-00093) and by the Association for Research Against Cancer (ARC). E. Ullrich was supported by the Deutsche Forschungsgemeinschaft and M. Bonmort by the Poste d{\textquoteright} Accueil INSERM. This work was also supported by EU grants (ALLOSTEM, DC THERA), ARC and the Ligue Nationale contre le Cancer ({\'e}quipes labelis{\'e}es de G.K. and L.Z).",

year = "2006",

month = mar,

day = "14",

doi = "10.1038/nm1356",

language = "English",

volume = "12",

pages = "214--219",

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Taieb, J, Chaput, N, Ménard, C, Apetoh, L, Ullrich, E, Bonmort, M, Péquignot, M, Casares, N, Terme, M, Flament, C, Opolon, P, Lecluse, Y, Métivier, D, Tomasello, E, Vivier, E, Ghiringhelli, F, Martin, F, Klatzmann, D, Poynard, T, Tursz, T, Raposo, G, Yagita, H, Ryffel, B, Kroemer, G & Zitvogel, L 2006, 'A novel dendritic cell subset involved in tumor immunosurveillance', Nature Medicine, VOL. 12, Numéro 2, p. 214-219. https://doi.org/10.1038/nm1356

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T1 - A novel dendritic cell subset involved in tumor immunosurveillance

AU - Taieb, Julien

AU - Chaput, Nathalie

AU - Ménard, Cédric

AU - Apetoh, Lionel

AU - Ullrich, Evelyn

AU - Bonmort, Mathieu

AU - Péquignot, Marie

AU - Casares, Noelia

AU - Terme, Magali

AU - Flament, Caroline

AU - Opolon, Paule

AU - Lecluse, Yann

AU - Métivier, Didier

AU - Tomasello, Elena

AU - Vivier, Eric

AU - Ghiringhelli, François

AU - Martin, François

AU - Klatzmann, David

AU - Poynard, Thierry

AU - Tursz, Thomas

AU - Raposo, Graça

AU - Yagita, Hideo

AU - Ryffel, Bernard

AU - Kroemer, Guido

AU - Zitvogel, Laurence

N1 - Funding Information: We thank F. Housseau for communicating his data on IKDCs and providing reagents, J. Tschopp (University of Lausanne) and G. Salvesen (Burnham Institute) for providing plasmids and M.L. Albert (Pasteur Institute) for providing reagents. J. Taieb is supported by a Poste d’accueil INSERM and AP-HP, and N. Chaput is supported by a European fellowship (QLRT-2001-00093) and by the Association for Research Against Cancer (ARC). E. Ullrich was supported by the Deutsche Forschungsgemeinschaft and M. Bonmort by the Poste d’ Accueil INSERM. This work was also supported by EU grants (ALLOSTEM, DC THERA), ARC and the Ligue Nationale contre le Cancer (équipes labelisées de G.K. and L.Z).

PY - 2006/3/14

Y1 - 2006/3/14

N2 - The interferon (IFN)-γ-induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice 1,2. Here we show that the main source of IFN-γ is not the conventional NK cell but a subset of B220+Ly6C- dendritic cells, which are atypical insofar as they express NK cell-surface molecules. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220+NK1.1+ dendritic cells secrete high levels of IFN-γ and mediate TRAIL-dependent lysis of tumor cells. Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2-/-II2rg-/- mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not. In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response.

AB - The interferon (IFN)-γ-induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice 1,2. Here we show that the main source of IFN-γ is not the conventional NK cell but a subset of B220+Ly6C- dendritic cells, which are atypical insofar as they express NK cell-surface molecules. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220+NK1.1+ dendritic cells secrete high levels of IFN-γ and mediate TRAIL-dependent lysis of tumor cells. Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2-/-II2rg-/- mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not. In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response.

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