A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC

Nikos Papadimitriou; Emmanouil Bouras; Piet A. van den Brandt; David C. Muller; Areti Papadopoulou; Alicia K. Heath; Elena Critselis; Marc J. Gunter; Paolo Vineis; Pietro Ferrari; Elisabete Weiderpass; Heiner Boeing; Nadia Bastide; Melissa A. Merritt; David S. Lopez; Manuela M. Bergmann; Aurora Perez-Cornago; Matthias Schulze; Guri Skeie; Bernard Srour; Anne Kirstine Eriksen; Stina Boden; Ingegerd Johansson; Therese Haugdahl Nøst; Marco Lukic; Fulvio Ricceri; Ulrika Ericson; José María Huerta; Christina C. Dahm; Claudia Agnoli; Pilar Exezarreta Amiano; Anne Tjønneland; Aurelio Barricarte Gurrea; Bas Bueno-de-Mesquita; Eva Ardanaz; Jonna Berntsson; Maria Jose Sánchez; Rosario Tumino; Salvatore Panico; Verena Katzke; Paula Jakszyn; Giovanna Masala; Jeroen W.G. Derksen; J. Ramón Quirós; Gianluca Severi; Amanda J. Cross; Ellio Riboli; Ioanna Tzoulaki; Konstantinos K. Tsilidis

doi:10.1016/j.cgh.2021.04.028

A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC

Nikos Papadimitriou, Emmanouil Bouras, Piet A. van den Brandt, David C. Muller, Areti Papadopoulou, Alicia K. Heath, Elena Critselis, Marc J. Gunter, Paolo Vineis, Pietro Ferrari, Elisabete Weiderpass, Heiner Boeing, Nadia Bastide, Melissa A. Merritt, David S. Lopez, Manuela M. Bergmann, Aurora Perez-Cornago, Matthias Schulze, Guri Skeie, Bernard SrourAnne Kirstine Eriksen, Stina Boden, Ingegerd Johansson, Therese Haugdahl Nøst, Marco Lukic, Fulvio Ricceri, Ulrika Ericson, José María Huerta, Christina C. Dahm, Claudia Agnoli, Pilar Exezarreta Amiano, Anne Tjønneland, Aurelio Barricarte Gurrea, Bas Bueno-de-Mesquita, Eva Ardanaz, Jonna Berntsson, Maria Jose Sánchez, Rosario Tumino, Salvatore Panico, Verena Katzke, Paula Jakszyn, Giovanna Masala, Jeroen W.G. Derksen, J. Ramón Quirós, Gianluca Severi, Amanda J. Cross, Ellio Riboli, Ioanna Tzoulaki, Konstantinos K. Tsilidis

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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Résumé

Background & Aims: Evidence regarding the association of dietary exposures with colorectal cancer (CRC) risk is not consistent with a few exceptions. Therefore, we conducted a diet-wide association study (DWAS) in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the associations between several dietary exposures with CRC risk. Methods: The association of 92 food and nutrient intakes with CRC risk was assessed in 386,792 participants, 5069 of whom developed incident CRC. Correction for multiple comparisons was performed using the false discovery rate, and emerging associations were examined in the Netherlands Cohort Study (NLCS). Multiplicative gene-nutrient interactions were also tested in EPIC based on known CRC-associated loci. Results: In EPIC, alcohol, liquor/spirits, wine, beer/cider, soft drinks, and pork were positively associated with CRC, whereas milk, cheese, calcium, phosphorus, magnesium, potassium, riboflavin, vitamin B6, beta carotene, fruit, fiber, nonwhite bread, banana, and total protein intakes were inversely associated. Of these 20 associations, 13 were replicated in the NLCS, for which a meta-analysis was performed, namely alcohol (summary hazard ratio [HR] per 1-SD increment in intake: 1.07; 95% confidence interval [CI], 1.04–1.09), liquor/spirits (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02–1.06), wine (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02–1.07), beer/cider (HR per 1-SD increment in intake, 1.06; 95% CI, 1.04–1.08), milk (HR per 1-SD increment in intake, 0.95; 95% CI, 0.93–0.98), cheese (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94–0.99), calcium (HR per 1-SD increment in intake, 0.93; 95% CI, 0.90–0.95), phosphorus (HR per 1-SD increment in intake, 0.92; 95% CI, 0.90–0.95), magnesium (HR per 1-SD increment in intake, 0.95; 95% CI, 0.92–0.98), potassium (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94–0.99), riboflavin (HR per 1-SD increment in intake, 0.94; 95% CI, 0.92–0.97), beta carotene (HR per 1-SD increment in intake, 0.96; 95% CI, 0.93–0.98), and total protein (HR per 1-SD increment in intake, 0.94; 95% CI, 0.92–0.97). None of the gene-nutrient interactions were significant after adjustment for multiple comparisons. Conclusions: Our findings confirm a positive association for alcohol and an inverse association for dairy products and calcium with CRC risk, and also suggest a lower risk at higher dietary intakes of phosphorus, magnesium, potassium, riboflavin, beta carotene, and total protein.

langue originale	Anglais
Pages (de - à)	864-873.e13
journal	Clinical Gastroenterology and Hepatology
Volume	20
Numéro de publication	4
Les DOIs	https://doi.org/10.1016/j.cgh.2021.04.028
état	Publié - 1 avr. 2022

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10.1016/j.cgh.2021.04.028

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Papadimitriou, N., Bouras, E., van den Brandt, P. A., Muller, D. C., Papadopoulou, A., Heath, A. K., Critselis, E., Gunter, M. J., Vineis, P., Ferrari, P., Weiderpass, E., Boeing, H., Bastide, N., Merritt, M. A., Lopez, D. S., Bergmann, M. M., Perez-Cornago, A., Schulze, M., Skeie, G., ... Tsilidis, K. K. (2022). A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC. Clinical Gastroenterology and Hepatology, 20(4), 864-873.e13. https://doi.org/10.1016/j.cgh.2021.04.028

@article{c1ff710d25f045b7baee2385fcd05b88,

title = "A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC",

abstract = "Background & Aims: Evidence regarding the association of dietary exposures with colorectal cancer (CRC) risk is not consistent with a few exceptions. Therefore, we conducted a diet-wide association study (DWAS) in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the associations between several dietary exposures with CRC risk. Methods: The association of 92 food and nutrient intakes with CRC risk was assessed in 386,792 participants, 5069 of whom developed incident CRC. Correction for multiple comparisons was performed using the false discovery rate, and emerging associations were examined in the Netherlands Cohort Study (NLCS). Multiplicative gene-nutrient interactions were also tested in EPIC based on known CRC-associated loci. Results: In EPIC, alcohol, liquor/spirits, wine, beer/cider, soft drinks, and pork were positively associated with CRC, whereas milk, cheese, calcium, phosphorus, magnesium, potassium, riboflavin, vitamin B6, beta carotene, fruit, fiber, nonwhite bread, banana, and total protein intakes were inversely associated. Of these 20 associations, 13 were replicated in the NLCS, for which a meta-analysis was performed, namely alcohol (summary hazard ratio [HR] per 1-SD increment in intake: 1.07; 95% confidence interval [CI], 1.04–1.09), liquor/spirits (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02–1.06), wine (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02–1.07), beer/cider (HR per 1-SD increment in intake, 1.06; 95% CI, 1.04–1.08), milk (HR per 1-SD increment in intake, 0.95; 95% CI, 0.93–0.98), cheese (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94–0.99), calcium (HR per 1-SD increment in intake, 0.93; 95% CI, 0.90–0.95), phosphorus (HR per 1-SD increment in intake, 0.92; 95% CI, 0.90–0.95), magnesium (HR per 1-SD increment in intake, 0.95; 95% CI, 0.92–0.98), potassium (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94–0.99), riboflavin (HR per 1-SD increment in intake, 0.94; 95% CI, 0.92–0.97), beta carotene (HR per 1-SD increment in intake, 0.96; 95% CI, 0.93–0.98), and total protein (HR per 1-SD increment in intake, 0.94; 95% CI, 0.92–0.97). None of the gene-nutrient interactions were significant after adjustment for multiple comparisons. Conclusions: Our findings confirm a positive association for alcohol and an inverse association for dairy products and calcium with CRC risk, and also suggest a lower risk at higher dietary intakes of phosphorus, magnesium, potassium, riboflavin, beta carotene, and total protein.",

keywords = "cohort study, colorectal cancer, epidemiology, nutrition",

author = "Nikos Papadimitriou and Emmanouil Bouras and {van den Brandt}, {Piet A.} and Muller, {David C.} and Areti Papadopoulou and Heath, {Alicia K.} and Elena Critselis and Gunter, {Marc J.} and Paolo Vineis and Pietro Ferrari and Elisabete Weiderpass and Heiner Boeing and Nadia Bastide and Merritt, {Melissa A.} and Lopez, {David S.} and Bergmann, {Manuela M.} and Aurora Perez-Cornago and Matthias Schulze and Guri Skeie and Bernard Srour and Eriksen, {Anne Kirstine} and Stina Boden and Ingegerd Johansson and N{\o}st, {Therese Haugdahl} and Marco Lukic and Fulvio Ricceri and Ulrika Ericson and Huerta, {Jos{\'e} Mar{\'i}a} and Dahm, {Christina C.} and Claudia Agnoli and Amiano, {Pilar Exezarreta} and Anne Tj{\o}nneland and Gurrea, {Aurelio Barricarte} and Bas Bueno-de-Mesquita and Eva Ardanaz and Jonna Berntsson and S{\'a}nchez, {Maria Jose} and Rosario Tumino and Salvatore Panico and Verena Katzke and Paula Jakszyn and Giovanna Masala and Derksen, {Jeroen W.G.} and Quir{\'o}s, {J. Ram{\'o}n} and Gianluca Severi and Cross, {Amanda J.} and Ellio Riboli and Ioanna Tzoulaki and Tsilidis, {Konstantinos K.}",

note = "Publisher Copyright: {\textcopyright} 2022 AGA Institute",

year = "2022",

month = apr,

day = "1",

doi = "10.1016/j.cgh.2021.04.028",

language = "English",

volume = "20",

pages = "864--873.e13",

journal = "Clinical Gastroenterology and Hepatology",

issn = "1542-3565",

number = "4",

}

Papadimitriou, N, Bouras, E, van den Brandt, PA, Muller, DC, Papadopoulou, A, Heath, AK, Critselis, E, Gunter, MJ, Vineis, P, Ferrari, P, Weiderpass, E, Boeing, H, Bastide, N, Merritt, MA, Lopez, DS, Bergmann, MM, Perez-Cornago, A, Schulze, M, Skeie, G, Srour, B, Eriksen, AK, Boden, S, Johansson, I, Nøst, TH, Lukic, M, Ricceri, F, Ericson, U, Huerta, JM, Dahm, CC, Agnoli, C, Amiano, PE, Tjønneland, A, Gurrea, AB, Bueno-de-Mesquita, B, Ardanaz, E, Berntsson, J, Sánchez, MJ, Tumino, R, Panico, S, Katzke, V, Jakszyn, P, Masala, G, Derksen, JWG, Quirós, JR, Severi, G, Cross, AJ, Riboli, E, Tzoulaki, I & Tsilidis, KK 2022, 'A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC', Clinical Gastroenterology and Hepatology, VOL. 20, Numéro 4, p. 864-873.e13. https://doi.org/10.1016/j.cgh.2021.04.028

TY - JOUR

T1 - A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC

AU - Papadimitriou, Nikos

AU - Bouras, Emmanouil

AU - van den Brandt, Piet A.

AU - Muller, David C.

AU - Papadopoulou, Areti

AU - Heath, Alicia K.

AU - Critselis, Elena

AU - Gunter, Marc J.

AU - Vineis, Paolo

AU - Ferrari, Pietro

AU - Weiderpass, Elisabete

AU - Boeing, Heiner

AU - Bastide, Nadia

AU - Merritt, Melissa A.

AU - Lopez, David S.

AU - Bergmann, Manuela M.

AU - Perez-Cornago, Aurora

AU - Schulze, Matthias

AU - Skeie, Guri

AU - Srour, Bernard

AU - Eriksen, Anne Kirstine

AU - Boden, Stina

AU - Johansson, Ingegerd

AU - Nøst, Therese Haugdahl

AU - Lukic, Marco

AU - Ricceri, Fulvio

AU - Ericson, Ulrika

AU - Huerta, José María

AU - Dahm, Christina C.

AU - Agnoli, Claudia

AU - Amiano, Pilar Exezarreta

AU - Tjønneland, Anne

AU - Gurrea, Aurelio Barricarte

AU - Bueno-de-Mesquita, Bas

AU - Ardanaz, Eva

AU - Berntsson, Jonna

AU - Sánchez, Maria Jose

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Katzke, Verena

AU - Jakszyn, Paula

AU - Masala, Giovanna

AU - Derksen, Jeroen W.G.

AU - Quirós, J. Ramón

AU - Severi, Gianluca

AU - Cross, Amanda J.

AU - Riboli, Ellio

AU - Tzoulaki, Ioanna

AU - Tsilidis, Konstantinos K.

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Background & Aims: Evidence regarding the association of dietary exposures with colorectal cancer (CRC) risk is not consistent with a few exceptions. Therefore, we conducted a diet-wide association study (DWAS) in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the associations between several dietary exposures with CRC risk. Methods: The association of 92 food and nutrient intakes with CRC risk was assessed in 386,792 participants, 5069 of whom developed incident CRC. Correction for multiple comparisons was performed using the false discovery rate, and emerging associations were examined in the Netherlands Cohort Study (NLCS). Multiplicative gene-nutrient interactions were also tested in EPIC based on known CRC-associated loci. Results: In EPIC, alcohol, liquor/spirits, wine, beer/cider, soft drinks, and pork were positively associated with CRC, whereas milk, cheese, calcium, phosphorus, magnesium, potassium, riboflavin, vitamin B6, beta carotene, fruit, fiber, nonwhite bread, banana, and total protein intakes were inversely associated. Of these 20 associations, 13 were replicated in the NLCS, for which a meta-analysis was performed, namely alcohol (summary hazard ratio [HR] per 1-SD increment in intake: 1.07; 95% confidence interval [CI], 1.04–1.09), liquor/spirits (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02–1.06), wine (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02–1.07), beer/cider (HR per 1-SD increment in intake, 1.06; 95% CI, 1.04–1.08), milk (HR per 1-SD increment in intake, 0.95; 95% CI, 0.93–0.98), cheese (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94–0.99), calcium (HR per 1-SD increment in intake, 0.93; 95% CI, 0.90–0.95), phosphorus (HR per 1-SD increment in intake, 0.92; 95% CI, 0.90–0.95), magnesium (HR per 1-SD increment in intake, 0.95; 95% CI, 0.92–0.98), potassium (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94–0.99), riboflavin (HR per 1-SD increment in intake, 0.94; 95% CI, 0.92–0.97), beta carotene (HR per 1-SD increment in intake, 0.96; 95% CI, 0.93–0.98), and total protein (HR per 1-SD increment in intake, 0.94; 95% CI, 0.92–0.97). None of the gene-nutrient interactions were significant after adjustment for multiple comparisons. Conclusions: Our findings confirm a positive association for alcohol and an inverse association for dairy products and calcium with CRC risk, and also suggest a lower risk at higher dietary intakes of phosphorus, magnesium, potassium, riboflavin, beta carotene, and total protein.

AB - Background & Aims: Evidence regarding the association of dietary exposures with colorectal cancer (CRC) risk is not consistent with a few exceptions. Therefore, we conducted a diet-wide association study (DWAS) in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the associations between several dietary exposures with CRC risk. Methods: The association of 92 food and nutrient intakes with CRC risk was assessed in 386,792 participants, 5069 of whom developed incident CRC. Correction for multiple comparisons was performed using the false discovery rate, and emerging associations were examined in the Netherlands Cohort Study (NLCS). Multiplicative gene-nutrient interactions were also tested in EPIC based on known CRC-associated loci. Results: In EPIC, alcohol, liquor/spirits, wine, beer/cider, soft drinks, and pork were positively associated with CRC, whereas milk, cheese, calcium, phosphorus, magnesium, potassium, riboflavin, vitamin B6, beta carotene, fruit, fiber, nonwhite bread, banana, and total protein intakes were inversely associated. Of these 20 associations, 13 were replicated in the NLCS, for which a meta-analysis was performed, namely alcohol (summary hazard ratio [HR] per 1-SD increment in intake: 1.07; 95% confidence interval [CI], 1.04–1.09), liquor/spirits (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02–1.06), wine (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02–1.07), beer/cider (HR per 1-SD increment in intake, 1.06; 95% CI, 1.04–1.08), milk (HR per 1-SD increment in intake, 0.95; 95% CI, 0.93–0.98), cheese (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94–0.99), calcium (HR per 1-SD increment in intake, 0.93; 95% CI, 0.90–0.95), phosphorus (HR per 1-SD increment in intake, 0.92; 95% CI, 0.90–0.95), magnesium (HR per 1-SD increment in intake, 0.95; 95% CI, 0.92–0.98), potassium (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94–0.99), riboflavin (HR per 1-SD increment in intake, 0.94; 95% CI, 0.92–0.97), beta carotene (HR per 1-SD increment in intake, 0.96; 95% CI, 0.93–0.98), and total protein (HR per 1-SD increment in intake, 0.94; 95% CI, 0.92–0.97). None of the gene-nutrient interactions were significant after adjustment for multiple comparisons. Conclusions: Our findings confirm a positive association for alcohol and an inverse association for dairy products and calcium with CRC risk, and also suggest a lower risk at higher dietary intakes of phosphorus, magnesium, potassium, riboflavin, beta carotene, and total protein.

KW - cohort study

KW - colorectal cancer

KW - epidemiology

KW - nutrition

UR - http://www.scopus.com/inward/record.url?scp=85111401409&partnerID=8YFLogxK

U2 - 10.1016/j.cgh.2021.04.028

DO - 10.1016/j.cgh.2021.04.028

M3 - Article

C2 - 33901663

AN - SCOPUS:85111401409

SN - 1542-3565

VL - 20

SP - 864-873.e13

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

IS - 4

ER -