A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk

Krasimira Aleksandrova; Shu Chun Chuang; Heiner Boeing; Hui Zuo; Grethe S. Tell; Tobias Pischon; Mazda Jenab; Bas Bueno-De-Mesquita; Stein Emil Vollset; Øivind Midttun; Per Magne Ueland; Veronika Fedirko; Mattias Johansson; Elisabete Weiderpass; Gianluca Severi; Antoine Racine; Marie Christine Boutron-Ruault; Rudolf Kaaks; Tilman Kühn; Anne Tjønneland; Kim Overvad; J. Ramón Quirós; Paula Jakszyn; María José Sánchez; Miren Dorronsoro; Maria Dolores Chirlaque; Eva Ardanaz; Kay Tee Khaw; Nicholas J. Wareham; Ruth C. Travis; Antonia Trichopoulou; Pagona Lagiou; Dimitrios Trichopoulos; Domenico Palli; Sabina Sieri; Rosario Tumino; Salvatore Panico; Anne M. May; Richard Palmqvist; Ingrid Ljuslinder; So Yeon J. Kong; Heinz Freisling; Marc J. Gunter; Yunxia Lu; Amanda J. Cross; Elio Riboli; Paolo Vineis

doi:10.1093/jnci/djv010

A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk

Krasimira Aleksandrova, Shu Chun Chuang, Heiner Boeing, Hui Zuo, Grethe S. Tell, Tobias Pischon, Mazda Jenab, Bas Bueno-De-Mesquita, Stein Emil Vollset, Øivind Midttun, Per Magne Ueland, Veronika Fedirko, Mattias Johansson, Elisabete Weiderpass, Gianluca Severi, Antoine Racine, Marie Christine Boutron-Ruault, Rudolf Kaaks, Tilman Kühn, Anne TjønnelandKim Overvad, J. Ramón Quirós, Paula Jakszyn, María José Sánchez, Miren Dorronsoro, Maria Dolores Chirlaque, Eva Ardanaz, Kay Tee Khaw, Nicholas J. Wareham, Ruth C. Travis, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Sabina Sieri, Rosario Tumino, Salvatore Panico, Anne M. May, Richard Palmqvist, Ingrid Ljuslinder, So Yeon J. Kong, Heinz Freisling, Marc J. Gunter, Yunxia Lu, Amanda J. Cross, Elio Riboli, Paolo Vineis

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

18 Citations (Scopus)

Résumé

Background: Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. Methods: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. Results: After multivariable adjustment for a priori chosen CRC risk factors, a "U-shaped" association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P _difference =. 87) and after excluding case patients diagnosed within the first four follow-up years. Conclusions: These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC.

langue originale	Anglais
journal	Journal of the National Cancer Institute
Volume	107
Numéro de publication	4
Les DOIs	https://doi.org/10.1093/jnci/djv010
état	Publié - 1 avr. 2015
Modification externe	Oui

Accès au document

10.1093/jnci/djv010

Autres fichiers et liens

Lien vers la publication dans Scopus

Contient cette citation

Aleksandrova, K., Chuang, S. C., Boeing, H., Zuo, H., Tell, G. S., Pischon, T., Jenab, M., Bueno-De-Mesquita, B., Vollset, S. E., Midttun, Ø., Ueland, P. M., Fedirko, V., Johansson, M., Weiderpass, E., Severi, G., Racine, A., Boutron-Ruault, M. C., Kaaks, R., Kühn, T., ... Vineis, P. (2015). A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk. Journal of the National Cancer Institute, 107(4). https://doi.org/10.1093/jnci/djv010

@article{af0fae34aa1440288bf0083c599e2bab,

title = "A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk",

abstract = "Background: Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. Methods: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. Results: After multivariable adjustment for a priori chosen CRC risk factors, a {"}U-shaped{"} association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P difference =. 87) and after excluding case patients diagnosed within the first four follow-up years. Conclusions: These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC.",

author = "Krasimira Aleksandrova and Chuang, {Shu Chun} and Heiner Boeing and Hui Zuo and Tell, {Grethe S.} and Tobias Pischon and Mazda Jenab and Bas Bueno-De-Mesquita and Vollset, {Stein Emil} and {\O}ivind Midttun and Ueland, {Per Magne} and Veronika Fedirko and Mattias Johansson and Elisabete Weiderpass and Gianluca Severi and Antoine Racine and Boutron-Ruault, {Marie Christine} and Rudolf Kaaks and Tilman K{\"u}hn and Anne Tj{\o}nneland and Kim Overvad and Quir{\'o}s, {J. Ram{\'o}n} and Paula Jakszyn and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Miren Dorronsoro and Chirlaque, {Maria Dolores} and Eva Ardanaz and Khaw, {Kay Tee} and Wareham, {Nicholas J.} and Travis, {Ruth C.} and Antonia Trichopoulou and Pagona Lagiou and Dimitrios Trichopoulos and Domenico Palli and Sabina Sieri and Rosario Tumino and Salvatore Panico and May, {Anne M.} and Richard Palmqvist and Ingrid Ljuslinder and Kong, {So Yeon J.} and Heinz Freisling and Gunter, {Marc J.} and Yunxia Lu and Cross, {Amanda J.} and Elio Riboli and Paolo Vineis",

year = "2015",

month = apr,

day = "1",

doi = "10.1093/jnci/djv010",

language = "English",

volume = "107",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

number = "4",

}

Aleksandrova, K, Chuang, SC, Boeing, H, Zuo, H, Tell, GS, Pischon, T, Jenab, M, Bueno-De-Mesquita, B, Vollset, SE, Midttun, Ø, Ueland, PM, Fedirko, V, Johansson, M, Weiderpass, E, Severi, G, Racine, A, Boutron-Ruault, MC, Kaaks, R, Kühn, T, Tjønneland, A, Overvad, K, Quirós, JR, Jakszyn, P, Sánchez, MJ, Dorronsoro, M, Chirlaque, MD, Ardanaz, E, Khaw, KT, Wareham, NJ, Travis, RC, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Sieri, S, Tumino, R, Panico, S, May, AM, Palmqvist, R, Ljuslinder, I, Kong, SYJ, Freisling, H, Gunter, MJ, Lu, Y, Cross, AJ, Riboli, E & Vineis, P 2015, 'A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk', Journal of the National Cancer Institute, VOL. 107, Numéro 4. https://doi.org/10.1093/jnci/djv010

TY - JOUR

T1 - A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk

AU - Aleksandrova, Krasimira

AU - Chuang, Shu Chun

AU - Boeing, Heiner

AU - Zuo, Hui

AU - Tell, Grethe S.

AU - Pischon, Tobias

AU - Jenab, Mazda

AU - Bueno-De-Mesquita, Bas

AU - Vollset, Stein Emil

AU - Midttun, Øivind

AU - Ueland, Per Magne

AU - Fedirko, Veronika

AU - Johansson, Mattias

AU - Weiderpass, Elisabete

AU - Severi, Gianluca

AU - Racine, Antoine

AU - Boutron-Ruault, Marie Christine

AU - Kaaks, Rudolf

AU - Kühn, Tilman

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Quirós, J. Ramón

AU - Jakszyn, Paula

AU - Sánchez, María José

AU - Dorronsoro, Miren

AU - Chirlaque, Maria Dolores

AU - Ardanaz, Eva

AU - Khaw, Kay Tee

AU - Wareham, Nicholas J.

AU - Travis, Ruth C.

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Sieri, Sabina

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - May, Anne M.

AU - Palmqvist, Richard

AU - Ljuslinder, Ingrid

AU - Kong, So Yeon J.

AU - Freisling, Heinz

AU - Gunter, Marc J.

AU - Lu, Yunxia

AU - Cross, Amanda J.

AU - Riboli, Elio

AU - Vineis, Paolo

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background: Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. Methods: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. Results: After multivariable adjustment for a priori chosen CRC risk factors, a "U-shaped" association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P difference =. 87) and after excluding case patients diagnosed within the first four follow-up years. Conclusions: These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC.

AB - Background: Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. Methods: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. Results: After multivariable adjustment for a priori chosen CRC risk factors, a "U-shaped" association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P difference =. 87) and after excluding case patients diagnosed within the first four follow-up years. Conclusions: These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC.

UR - http://www.scopus.com/inward/record.url?scp=84930701125&partnerID=8YFLogxK

U2 - 10.1093/jnci/djv010

DO - 10.1093/jnci/djv010

M3 - Article

C2 - 25713165

AN - SCOPUS:84930701125

SN - 0027-8874

VL - 107

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 4

ER -