A rare case of acute myeloid leukemia with t(12;19)(q13;q13)

Alain Chebly; Fady Gh Haddad; Josiane Bassil; Tony Yammine; Rima Korban; Warde Semaan; Fady El Karak; Hampig Raphael Kourie; Chantal Farra

doi:10.1016/j.lrr.2020.100216

A rare case of acute myeloid leukemia with t(12;19)(q13;q13)

Alain Chebly, Fady Gh Haddad, Josiane Bassil, Tony Yammine, Rima Korban, Warde Semaan, Fady El Karak, Hampig Raphael Kourie, Chantal Farra

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Résumé

Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities. We herein, report a rare balanced translocation t(12;19)(q13;q13) in a 66-year old M5-AML patient identified by Conventional cytogenetic analysis and confirmed by SNP array. We suggest that t(12;19) as a sole chromosomal abnormality could be associated with a poor prognosis. Further studies are needed to understand the molecular basis of this translocation in AML.

langue originale	Anglais
Numéro d'article	100216
journal	Leukemia Research Reports
Volume	14
Les DOIs	https://doi.org/10.1016/j.lrr.2020.100216
état	Publié - 1 janv. 2020
Modification externe	Oui

Accès au document

10.1016/j.lrr.2020.100216

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title = "A rare case of acute myeloid leukemia with t(12;19)(q13;q13)",

abstract = "Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities. We herein, report a rare balanced translocation t(12;19)(q13;q13) in a 66-year old M5-AML patient identified by Conventional cytogenetic analysis and confirmed by SNP array. We suggest that t(12;19) as a sole chromosomal abnormality could be associated with a poor prognosis. Further studies are needed to understand the molecular basis of this translocation in AML.",

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author = "Alain Chebly and Haddad, {Fady Gh} and Josiane Bassil and Tony Yammine and Rima Korban and Warde Semaan and {El Karak}, Fady and Kourie, {Hampig Raphael} and Chantal Farra",

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doi = "10.1016/j.lrr.2020.100216",

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T1 - A rare case of acute myeloid leukemia with t(12;19)(q13;q13)

AU - Chebly, Alain

AU - Haddad, Fady Gh

AU - Bassil, Josiane

AU - Yammine, Tony

AU - Korban, Rima

AU - Semaan, Warde

AU - El Karak, Fady

AU - Kourie, Hampig Raphael

AU - Farra, Chantal

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities. We herein, report a rare balanced translocation t(12;19)(q13;q13) in a 66-year old M5-AML patient identified by Conventional cytogenetic analysis and confirmed by SNP array. We suggest that t(12;19) as a sole chromosomal abnormality could be associated with a poor prognosis. Further studies are needed to understand the molecular basis of this translocation in AML.

AB - Acute myeloid leukemia (AML) is characterized by chromosomal abnormalities affecting both prognosis and course of treatment. While most AML patients have well described chromosomal aberrations, around 10% present with rare chromosomal abnormalities. We herein, report a rare balanced translocation t(12;19)(q13;q13) in a 66-year old M5-AML patient identified by Conventional cytogenetic analysis and confirmed by SNP array. We suggest that t(12;19) as a sole chromosomal abnormality could be associated with a poor prognosis. Further studies are needed to understand the molecular basis of this translocation in AML.

KW - AML

KW - Acute myeloid leukemia

KW - Cytogenetic

KW - Karyotype

KW - M5

KW - t(12;19)

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DO - 10.1016/j.lrr.2020.100216

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JO - Leukemia Research Reports

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