A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Baptiste Janela, Amit A. Patel, Mai Chan Lau, Chi Ching Goh, Rasha Msallam, Wan Ting Kong, Michael Fehlings, Sandra Hubert, Josephine Lum, Yannick Simoni, Benoit Malleret, Francesca Zolezzi, Jinmiao Chen, Michael Poidinger, Ansuman T. Satpathy, Carlos Briseno, Christian Wohn, Bernard Malissen, Kenneth M. Murphy, Alexander A. MainiLeen Vanhoutte, Martin Guilliams, Emmanuel Vial, Laurent Hennequin, Evan Newell, Lai Guan Ng, Philippe Musette, Simon Yona, Feriel Hacini-Rachinel, Florent Ginhoux

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

48 Citations (Scopus)

Résumé

Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.

langue originaleAnglais
Pages (de - à)1069-1083.e8
journalImmunity
Volume50
Numéro de publication4
Les DOIs
étatPublié - 16 avr. 2019
Modification externeOui

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