TY - JOUR
T1 - A systematic review of long non-coding RNAs with a potential role in breast cancer
AU - Heidari, Reza
AU - Akbariqomi, Mostafa
AU - Asgari, Yazdan
AU - Ebrahimi, Diako
AU - Alinejad-Rokny, Hamid
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - The human transcriptome contains many non-coding RNAs (ncRNAs), which play important roles in gene regulation. Long noncoding RNAs (lncRNAs) are an important class of ncRNAs with lengths between 200 and 200,000 bases. Unlike mRNA, lncRNA lacks protein-coding features, specifically, open-reading frames, and start and stop codons. LncRNAs have been reported to play a role in the pathogenesis and progression of many cancers, including breast cancer (BC), acting as tumor suppressors or oncogenes. In this review, we systematically mined the literature to identify 65 BC-related lncRNAs. We then perform an integrative bioinformatics analysis to identify 14 lncRNAs with a potential regulatory role in BC. The biological function of these 14 lncRNAs, their regulatory mechanisms, and roles in the initiation and progression of BC are discussed in this review. Additionally, we elaborate on the current and future applications of lncRNAs as diagnostic and/or therapeutic biomarkers in BC.
AB - The human transcriptome contains many non-coding RNAs (ncRNAs), which play important roles in gene regulation. Long noncoding RNAs (lncRNAs) are an important class of ncRNAs with lengths between 200 and 200,000 bases. Unlike mRNA, lncRNA lacks protein-coding features, specifically, open-reading frames, and start and stop codons. LncRNAs have been reported to play a role in the pathogenesis and progression of many cancers, including breast cancer (BC), acting as tumor suppressors or oncogenes. In this review, we systematically mined the literature to identify 65 BC-related lncRNAs. We then perform an integrative bioinformatics analysis to identify 14 lncRNAs with a potential regulatory role in BC. The biological function of these 14 lncRNAs, their regulatory mechanisms, and roles in the initiation and progression of BC are discussed in this review. Additionally, we elaborate on the current and future applications of lncRNAs as diagnostic and/or therapeutic biomarkers in BC.
KW - Breast cancer
KW - Causative lncRNAs
KW - Gene prioritization
KW - Gene regulation
KW - Long non-coding RNA
KW - Therapeutic biomarkers
UR - http://www.scopus.com/inward/record.url?scp=85104420007&partnerID=8YFLogxK
U2 - 10.1016/j.mrrev.2021.108375
DO - 10.1016/j.mrrev.2021.108375
M3 - Review article
C2 - 34083033
AN - SCOPUS:85104420007
SN - 1383-5742
VL - 787
JO - Mutation Research - Reviews in Mutation Research
JF - Mutation Research - Reviews in Mutation Research
M1 - 108375
ER -