A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19

Joo Guan Yeo; Jing Yao Leong; Shi Huan Tay; Karen Donceras Nadua; Danielle E. Anderson; Amanda Jin Mei Lim; Xiang Wen Ng; Su Li Poh; Dianyan Guo; Katherine Nay Yaung; Pavanish Kumar; Martin Wasser; Sharifah Nur Hazirah; Nursyuhadah Sutamam; Camillus Jian Hui Chua; Martin Qui; Randy Foo; Akshamal Mihiranga Gamage; Kee Thai Yeo; Lakshmi Ramakrishna; Thaschawee Arkachaisri; Barnaby E. Young; David Chien Lye; Lin Fa Wang; Chia Yin Chong; Natalie Woon Hui Tan; Jiahui Li; Kai Qian Kam; Florent Ginhoux; Koh Cheng Thoon; Jerry Kok Yen Chan; Chee Fu Yung; Salvatore Albani

doi:10.3389/fimmu.2021.674279

A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19

Joo Guan Yeo, Jing Yao Leong, Shi Huan Tay, Karen Donceras Nadua, Danielle E. Anderson, Amanda Jin Mei Lim, Xiang Wen Ng, Su Li Poh, Dianyan Guo, Katherine Nay Yaung, Pavanish Kumar, Martin Wasser, Sharifah Nur Hazirah, Nursyuhadah Sutamam, Camillus Jian Hui Chua, Martin Qui, Randy Foo, Akshamal Mihiranga Gamage, Kee Thai Yeo, Lakshmi RamakrishnaThaschawee Arkachaisri, Barnaby E. Young, David Chien Lye, Lin Fa Wang, Chia Yin Chong, Natalie Woon Hui Tan, Jiahui Li, Kai Qian Kam, Florent Ginhoux, Koh Cheng Thoon, Jerry Kok Yen Chan, Chee Fu Yung, Salvatore Albani

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

4 Citations (Scopus)

Résumé

An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (T_eff) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (T_reg) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFNγ⁺ memory CD4⁺ T cells and virus-specific follicular helper T (T_FH) cells. Overall, these findings pinpoint critical immune effector and regulatory mechanisms essential for a potent, yet harmless resolution of COVID-19 infection.

langue originale	Anglais
Numéro d'article	674279
journal	Frontiers in Immunology
Volume	12
Les DOIs	https://doi.org/10.3389/fimmu.2021.674279
état	Publié - 25 mai 2021
Modification externe	Oui

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10.3389/fimmu.2021.674279

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Yeo, J. G., Leong, J. Y., Tay, S. H., Nadua, K. D., Anderson, D. E., Lim, A. J. M., Ng, X. W., Poh, S. L., Guo, D., Yaung, K. N., Kumar, P., Wasser, M., Hazirah, S. N., Sutamam, N., Chua, C. J. H., Qui, M., Foo, R., Gamage, A. M., Yeo, K. T., ... Albani, S. (2021). A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19. Frontiers in Immunology, 12, Article 674279. https://doi.org/10.3389/fimmu.2021.674279

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title = "A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19",

abstract = "An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (Teff) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (Treg) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFNγ+ memory CD4+ T cells and virus-specific follicular helper T (TFH) cells. Overall, these findings pinpoint critical immune effector and regulatory mechanisms essential for a potent, yet harmless resolution of COVID-19 infection.",

keywords = "COVID-19, SARS-CoV-2, follicular helper T cells, mass cytometry, regulatory T cells",

author = "Yeo, {Joo Guan} and Leong, {Jing Yao} and Tay, {Shi Huan} and Nadua, {Karen Donceras} and Anderson, {Danielle E.} and Lim, {Amanda Jin Mei} and Ng, {Xiang Wen} and Poh, {Su Li} and Dianyan Guo and Yaung, {Katherine Nay} and Pavanish Kumar and Martin Wasser and Hazirah, {Sharifah Nur} and Nursyuhadah Sutamam and Chua, {Camillus Jian Hui} and Martin Qui and Randy Foo and Gamage, {Akshamal Mihiranga} and Yeo, {Kee Thai} and Lakshmi Ramakrishna and Thaschawee Arkachaisri and Young, {Barnaby E.} and Lye, {David Chien} and Wang, {Lin Fa} and Chong, {Chia Yin} and Tan, {Natalie Woon Hui} and Jiahui Li and Kam, {Kai Qian} and Florent Ginhoux and Thoon, {Koh Cheng} and Chan, {Jerry Kok Yen} and Yung, {Chee Fu} and Salvatore Albani",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Yeo, Leong, Tay, Nadua, Anderson, Lim, Ng, Poh, Guo, Yaung, Kumar, Wasser, Hazirah, Sutamam, Chua, Qui, Foo, Gamage, Yeo, Ramakrishna, Arkachaisri, Young, Lye, Wang, Chong, Tan, Li, Kam, Ginhoux, Thoon, Chan, Yung and Albani.",

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Yeo, JG, Leong, JY, Tay, SH, Nadua, KD, Anderson, DE, Lim, AJM, Ng, XW, Poh, SL, Guo, D, Yaung, KN, Kumar, P, Wasser, M, Hazirah, SN, Sutamam, N, Chua, CJH, Qui, M, Foo, R, Gamage, AM, Yeo, KT, Ramakrishna, L, Arkachaisri, T, Young, BE, Lye, DC, Wang, LF, Chong, CY, Tan, NWH, Li, J, Kam, KQ, Ginhoux, F, Thoon, KC, Chan, JKY, Yung, CF & Albani, S 2021, 'A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19', Frontiers in Immunology, VOL. 12, 674279. https://doi.org/10.3389/fimmu.2021.674279

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T1 - A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19

AU - Yeo, Joo Guan

AU - Leong, Jing Yao

AU - Tay, Shi Huan

AU - Nadua, Karen Donceras

AU - Anderson, Danielle E.

AU - Lim, Amanda Jin Mei

AU - Ng, Xiang Wen

AU - Poh, Su Li

AU - Guo, Dianyan

AU - Yaung, Katherine Nay

AU - Kumar, Pavanish

AU - Wasser, Martin

AU - Hazirah, Sharifah Nur

AU - Sutamam, Nursyuhadah

AU - Chua, Camillus Jian Hui

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AU - Yeo, Kee Thai

AU - Ramakrishna, Lakshmi

AU - Arkachaisri, Thaschawee

AU - Young, Barnaby E.

AU - Lye, David Chien

AU - Wang, Lin Fa

AU - Chong, Chia Yin

AU - Tan, Natalie Woon Hui

AU - Li, Jiahui

AU - Kam, Kai Qian

AU - Ginhoux, Florent

AU - Thoon, Koh Cheng

AU - Chan, Jerry Kok Yen

AU - Yung, Chee Fu

AU - Albani, Salvatore

N1 - Publisher Copyright: © Copyright © 2021 Yeo, Leong, Tay, Nadua, Anderson, Lim, Ng, Poh, Guo, Yaung, Kumar, Wasser, Hazirah, Sutamam, Chua, Qui, Foo, Gamage, Yeo, Ramakrishna, Arkachaisri, Young, Lye, Wang, Chong, Tan, Li, Kam, Ginhoux, Thoon, Chan, Yung and Albani.

PY - 2021/5/25

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N2 - An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (Teff) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (Treg) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFNγ+ memory CD4+ T cells and virus-specific follicular helper T (TFH) cells. Overall, these findings pinpoint critical immune effector and regulatory mechanisms essential for a potent, yet harmless resolution of COVID-19 infection.

AB - An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (Teff) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (Treg) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFNγ+ memory CD4+ T cells and virus-specific follicular helper T (TFH) cells. Overall, these findings pinpoint critical immune effector and regulatory mechanisms essential for a potent, yet harmless resolution of COVID-19 infection.

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