TY - JOUR
T1 - Acute megakaryoblastic leukemia and loss of the RUNX1 gene
AU - Berger, Roland
AU - Busson, Maryvonne
AU - Dastugue, Nicole
AU - Radford-Weiss, Isabelle
AU - Michaux, Lucienne
AU - Hagemeijer, Anne
AU - Quilichini, Benoît
AU - Benattar, Laurence
AU - Bernard, Olivier
AU - Romana, Serge P.
N1 - Funding Information:
This work was supported partially by INSERM and by the Comité de Paris de la Ligue Nationale Contre le Cancer (LNCC).
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Since the RUNX1 gene contributes to megakaryopoiesis and acquired trisomy 21 is the most frequent numerical chromosome anomaly in acute megakaryoblastic leukemia (AMLK), a systematic study of RUNX1 abnormalities was performed by fluorescence in situ hybridization in AMLK patients. Four abnormalities were detected among 15 patients. One copy of RUNX1 was completeley or partially lost in three patients and translocated onto Xq24 in the fourth. The possible consequences of RUNX1 haploinsufficiency are discussed.
AB - Since the RUNX1 gene contributes to megakaryopoiesis and acquired trisomy 21 is the most frequent numerical chromosome anomaly in acute megakaryoblastic leukemia (AMLK), a systematic study of RUNX1 abnormalities was performed by fluorescence in situ hybridization in AMLK patients. Four abnormalities were detected among 15 patients. One copy of RUNX1 was completeley or partially lost in three patients and translocated onto Xq24 in the fourth. The possible consequences of RUNX1 haploinsufficiency are discussed.
UR - http://www.scopus.com/inward/record.url?scp=29244440898&partnerID=8YFLogxK
U2 - 10.1016/j.cancergencyto.2005.05.002
DO - 10.1016/j.cancergencyto.2005.05.002
M3 - Article
C2 - 16364766
AN - SCOPUS:29244440898
SN - 0165-4608
VL - 164
SP - 71
EP - 73
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -