Acute megakaryoblastic leukemia (excluding Down syndrome) remains an acute myeloid subgroup with inferior outcome in the French ELAM02 trial

Anne Charlotte Teyssier; Hélène Lapillonne; Marlene Pasquet; Paola Ballerini; André Baruchel; Stephane Ducassou; Odile Fenneteau; Arnaud Petit; Wendy Cuccuini; Christine Ragu; Claude Preudhomme; Thomas Mercher; Nicolas Sirvent; Guy Leverger

doi:10.1080/08880018.2017.1414905

Acute megakaryoblastic leukemia (excluding Down syndrome) remains an acute myeloid subgroup with inferior outcome in the French ELAM02 trial

Anne Charlotte Teyssier, Hélène Lapillonne, Marlene Pasquet, Paola Ballerini, André Baruchel, Stephane Ducassou, Odile Fenneteau, Arnaud Petit, Wendy Cuccuini, Christine Ragu, Claude Preudhomme, Thomas Mercher, Nicolas Sirvent, Guy Leverger

Résultats de recherche: Contribution à un journal › Letter › Revue par des pairs

12 Citations (Scopus)

Résumé

We report the outcome of 27 children with de novo acute megakaryoblastic leukemia (AMKL) (excluding Down syndrome) enrolled in the French multicenter prospective study ELAM02 (2005-2011). There was no difference in gender, initial leukocyte count, CNS involvement, and complete remission rate (88.9%), as compared to other acute myeloid leukemia (AML) subtypes. AMKL patients had a significantly poorer outcome (5-year overall survival 54% [CI 95% 33%–71%] than children with other AML subtypes (5-year overall survival 73% [CI 95% 68%–77%] p = 0.02). Gender, age, CNS leukemia, hyperleukocytosis, complete remission or cytogenetic subgroups were not significant prognostic factors of disease-free survival. AMKL (excluding Down syndrom) remains an AML subgroup with inferior outcome.

langue originale	Anglais
Pages (de - à)	425-427
Nombre de pages	3
journal	Pediatric Hematology and Oncology
Volume	34
Numéro de publication	8
Les DOIs	https://doi.org/10.1080/08880018.2017.1414905
état	Publié - 17 nov. 2017

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10.1080/08880018.2017.1414905

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Teyssier, A. C., Lapillonne, H., Pasquet, M., Ballerini, P., Baruchel, A., Ducassou, S., Fenneteau, O., Petit, A., Cuccuini, W., Ragu, C., Preudhomme, C., Mercher, T., Sirvent, N., & Leverger, G. (2017). Acute megakaryoblastic leukemia (excluding Down syndrome) remains an acute myeloid subgroup with inferior outcome in the French ELAM02 trial. Pediatric Hematology and Oncology, 34(8), 425-427. https://doi.org/10.1080/08880018.2017.1414905

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title = "Acute megakaryoblastic leukemia (excluding Down syndrome) remains an acute myeloid subgroup with inferior outcome in the French ELAM02 trial",

abstract = "We report the outcome of 27 children with de novo acute megakaryoblastic leukemia (AMKL) (excluding Down syndrome) enrolled in the French multicenter prospective study ELAM02 (2005-2011). There was no difference in gender, initial leukocyte count, CNS involvement, and complete remission rate (88.9%), as compared to other acute myeloid leukemia (AML) subtypes. AMKL patients had a significantly poorer outcome (5-year overall survival 54% [CI 95% 33%–71%] than children with other AML subtypes (5-year overall survival 73% [CI 95% 68%–77%] p = 0.02). Gender, age, CNS leukemia, hyperleukocytosis, complete remission or cytogenetic subgroups were not significant prognostic factors of disease-free survival. AMKL (excluding Down syndrom) remains an AML subgroup with inferior outcome.",

keywords = "AMKL, ELAM02, pediatric acute megakaryoblastic leukemia",

author = "Teyssier, {Anne Charlotte} and H{\'e}l{\`e}ne Lapillonne and Marlene Pasquet and Paola Ballerini and Andr{\'e} Baruchel and Stephane Ducassou and Odile Fenneteau and Arnaud Petit and Wendy Cuccuini and Christine Ragu and Claude Preudhomme and Thomas Mercher and Nicolas Sirvent and Guy Leverger",

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year = "2017",

month = nov,

day = "17",

doi = "10.1080/08880018.2017.1414905",

language = "English",

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Teyssier, AC, Lapillonne, H, Pasquet, M, Ballerini, P, Baruchel, A, Ducassou, S, Fenneteau, O, Petit, A, Cuccuini, W, Ragu, C, Preudhomme, C, Mercher, T, Sirvent, N & Leverger, G 2017, 'Acute megakaryoblastic leukemia (excluding Down syndrome) remains an acute myeloid subgroup with inferior outcome in the French ELAM02 trial', Pediatric Hematology and Oncology, VOL. 34, Numéro 8, p. 425-427. https://doi.org/10.1080/08880018.2017.1414905

Acute megakaryoblastic leukemia (excluding Down syndrome) remains an acute myeloid subgroup with inferior outcome in the French ELAM02 trial. / Teyssier, Anne Charlotte; Lapillonne, Hélène; Pasquet, Marlene et al.
Dans: Pediatric Hematology and Oncology, Vol 34, Numéro 8, 17.11.2017, p. 425-427.

Résultats de recherche: Contribution à un journal › Letter › Revue par des pairs

TY - JOUR

T1 - Acute megakaryoblastic leukemia (excluding Down syndrome) remains an acute myeloid subgroup with inferior outcome in the French ELAM02 trial

AU - Teyssier, Anne Charlotte

AU - Lapillonne, Hélène

AU - Pasquet, Marlene

AU - Ballerini, Paola

AU - Baruchel, André

AU - Ducassou, Stephane

AU - Fenneteau, Odile

AU - Petit, Arnaud

AU - Cuccuini, Wendy

AU - Ragu, Christine

AU - Preudhomme, Claude

AU - Mercher, Thomas

AU - Sirvent, Nicolas

AU - Leverger, Guy

PY - 2017/11/17

Y1 - 2017/11/17

N2 - We report the outcome of 27 children with de novo acute megakaryoblastic leukemia (AMKL) (excluding Down syndrome) enrolled in the French multicenter prospective study ELAM02 (2005-2011). There was no difference in gender, initial leukocyte count, CNS involvement, and complete remission rate (88.9%), as compared to other acute myeloid leukemia (AML) subtypes. AMKL patients had a significantly poorer outcome (5-year overall survival 54% [CI 95% 33%–71%] than children with other AML subtypes (5-year overall survival 73% [CI 95% 68%–77%] p = 0.02). Gender, age, CNS leukemia, hyperleukocytosis, complete remission or cytogenetic subgroups were not significant prognostic factors of disease-free survival. AMKL (excluding Down syndrom) remains an AML subgroup with inferior outcome.

AB - We report the outcome of 27 children with de novo acute megakaryoblastic leukemia (AMKL) (excluding Down syndrome) enrolled in the French multicenter prospective study ELAM02 (2005-2011). There was no difference in gender, initial leukocyte count, CNS involvement, and complete remission rate (88.9%), as compared to other acute myeloid leukemia (AML) subtypes. AMKL patients had a significantly poorer outcome (5-year overall survival 54% [CI 95% 33%–71%] than children with other AML subtypes (5-year overall survival 73% [CI 95% 68%–77%] p = 0.02). Gender, age, CNS leukemia, hyperleukocytosis, complete remission or cytogenetic subgroups were not significant prognostic factors of disease-free survival. AMKL (excluding Down syndrom) remains an AML subgroup with inferior outcome.

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DO - 10.1080/08880018.2017.1414905

M3 - Letter

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AN - SCOPUS:85041424272

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JO - Pediatric Hematology and Oncology

JF - Pediatric Hematology and Oncology

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ER -