TY - JOUR
T1 - Adenovirus vectors for gene delivery
AU - Benihoud, Karim
AU - Yeh, Patrice
AU - Perricaudet, Michel
N1 - Funding Information:
UMR1582 laboratory members are acknowledged for critical discussion. We are most grateful to the ‘Association Française de Lutte contre la Mucoviscidose’ (AFLM), the ‘Association Française contre les Myopathies’, the CNRS and Rhône-Poulenc Rorer Gencell for support. K Benihoud is recipient of an AFLM fellowship.
PY - 1999/10/1
Y1 - 1999/10/1
N2 - Recent endeavors in the development of adenovirus as a gene vector have focused on the modification of virus tropism, the accomodation of larger genes, and the increase in stability and control of transgene expression. Whereas partial or total deletions of viral genes increase the cloning capacity and partly reduce the cellular immune response, control of the humoral response, which often precludes efficient readministration, remains a challenge.
AB - Recent endeavors in the development of adenovirus as a gene vector have focused on the modification of virus tropism, the accomodation of larger genes, and the increase in stability and control of transgene expression. Whereas partial or total deletions of viral genes increase the cloning capacity and partly reduce the cellular immune response, control of the humoral response, which often precludes efficient readministration, remains a challenge.
UR - http://www.scopus.com/inward/record.url?scp=0032834927&partnerID=8YFLogxK
U2 - 10.1016/S0958-1669(99)00007-5
DO - 10.1016/S0958-1669(99)00007-5
M3 - Review article
C2 - 10508634
AN - SCOPUS:0032834927
SN - 0958-1669
VL - 10
SP - 440
EP - 447
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
IS - 5
ER -