TY - JOUR
T1 - Age, COVID-19-like symptoms and SARS-CoV-2 seropositivity profiles after the first wave of the pandemic in France
AU - for the SAPRIS-SERO study group
AU - Carrat, Fabrice
AU - Lapidus, Nathanael
AU - Ninove, Laetitia
AU - Blanché, Hélène
AU - Rahib, Delphine
AU - Saba Villarroel, Paola Mariela
AU - Touvier, Mathilde
AU - Severi, Gianluca
AU - Zins, Marie
AU - Deleuze, Jean François
AU - de Lamballerie, Xavier
AU - Carrat, Fabrice
AU - Ancel, Pierre Yves
AU - Charles, Marie Aline
AU - Bajos, Nathalie
AU - Jusot, Florence
AU - Martin, Claude
AU - Meyer, Laurence
AU - Pailhé, Ariane
AU - Rouquette, Alexandra
AU - Spire, Alexis
AU - Kab, Sofiane
AU - Renuy, Adeline
AU - Le-Got, Stephane
AU - Ribet, Celine
AU - Wiernik, Emmanuel
AU - Goldberg, Marcel
AU - Artaud, Fanny
AU - Gerbouin-Rérolle, Pascale
AU - Enguix, Mélody
AU - Laplanche, Camille
AU - Gomes-Rima, Roselyn
AU - Hoang, Lyan
AU - Correia, Emmanuelle
AU - Barry, Alpha Amadou
AU - Senina, Nadège
AU - Allegre, Julien
AU - Szabo de Edelenyi, Fabien
AU - Druesne-Pecollo, Nathalie
AU - Esseddik, Younes
AU - Hercberg, Serge
AU - Benhammou, Valérie
AU - Ritmi, Anass
AU - Marchand, Laetitia
AU - Zaros, Cecile
AU - Lordmi, Elodie
AU - Candea, Adriana
AU - de Visme, Sophie
AU - Simeon, Thierry
AU - Thierry, Xavier
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Background: The interplay between age and symptoms intensity on antibody response to SARS-CoV-2 infection has not been studied in a general population setting. Methods: We explored the serologic profile of anti-SARS-CoV-2 antibodies after the first wave of the pandemic, by assessing IgG against the spike protein (ELISA-S), IgG against the nucleocapsid protein (ELISA-NP) and neutralizing antibodies (SN) in 82,126 adults from a French population-based multi-cohort study. Results: ELISA-S positivity was increased in 30- to 49-year-old adults (8.5%) compared to other age groups (5.6% in 20- to 29-year-olds, 2.8% in ≥ 50-year-olds). In the 3681 ELISA-S positive participants, ELISA-NP and SN positivity exhibited a U-shaped relationship with age, with a lower rate in 30- to 49-year-old adults, and was strongly associated with COVID-19-like symptoms. Conclusion: Our study confirms the independent role of age and symptoms on the serologic profile of anti-SARS-CoV-2 antibodies, but the non-linear relationship with age deserves further investigation.
AB - Background: The interplay between age and symptoms intensity on antibody response to SARS-CoV-2 infection has not been studied in a general population setting. Methods: We explored the serologic profile of anti-SARS-CoV-2 antibodies after the first wave of the pandemic, by assessing IgG against the spike protein (ELISA-S), IgG against the nucleocapsid protein (ELISA-NP) and neutralizing antibodies (SN) in 82,126 adults from a French population-based multi-cohort study. Results: ELISA-S positivity was increased in 30- to 49-year-old adults (8.5%) compared to other age groups (5.6% in 20- to 29-year-olds, 2.8% in ≥ 50-year-olds). In the 3681 ELISA-S positive participants, ELISA-NP and SN positivity exhibited a U-shaped relationship with age, with a lower rate in 30- to 49-year-old adults, and was strongly associated with COVID-19-like symptoms. Conclusion: Our study confirms the independent role of age and symptoms on the serologic profile of anti-SARS-CoV-2 antibodies, but the non-linear relationship with age deserves further investigation.
KW - COVID-19
KW - Cohort
KW - General population
KW - Neutralizing antibodies
KW - SARS-CoV-2
KW - Serologic profile
UR - http://www.scopus.com/inward/record.url?scp=85129391868&partnerID=8YFLogxK
U2 - 10.1007/s15010-021-01731-5
DO - 10.1007/s15010-021-01731-5
M3 - Article
AN - SCOPUS:85129391868
SN - 0300-8126
VL - 50
SP - 257
EP - 262
JO - Infection
JF - Infection
IS - 1
ER -