AID and partners: For better and (not) for worse

Sébastien Storck, Said Aoufouchi, Jean Claude Weill, Claude Agnès Reynaud

Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

34 Citations (Scopus)

Résumé

Post-rearrangement diversification of the antibody repertoire relies on a DNA editing factor, the cytidine deaminase AID. How B lymphocytes avoid generalized mutagenesis while expressing high levels of AID remained a long-standing question. Genome-wide studies of AID targeting combined to the discovery of several co-factors controlling its recruitment and its local activity shed new light on this enigma.

langue originaleAnglais
Pages (de - à)337-344
Nombre de pages8
journalCurrent Opinion in Immunology
Volume23
Numéro de publication3
Les DOIs
étatPublié - 1 juin 2011
Modification externeOui

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