Résumé
Post-rearrangement diversification of the antibody repertoire relies on a DNA editing factor, the cytidine deaminase AID. How B lymphocytes avoid generalized mutagenesis while expressing high levels of AID remained a long-standing question. Genome-wide studies of AID targeting combined to the discovery of several co-factors controlling its recruitment and its local activity shed new light on this enigma.
langue originale | Anglais |
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Pages (de - à) | 337-344 |
Nombre de pages | 8 |
journal | Current Opinion in Immunology |
Volume | 23 |
Numéro de publication | 3 |
Les DOIs | |
état | Publié - 1 juin 2011 |
Modification externe | Oui |