TY - JOUR
T1 - Alterations in cancer cell metabolism
T2 - The Warburg effect and metabolic adaptation
AU - Asgari, Yazdan
AU - Zabihinpour, Zahra
AU - Salehzadeh-Yazdi, Ali
AU - Schreiber, Falk
AU - Masoudi-Nejad, Ali
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - The Warburg effect means higher glucose uptake of cancer cells compared to normal tissues, whereas a smaller fraction of this glucose is employed for oxidative phosphorylation. With the advent of high throughput technologies and computational systems biology, cancer cell metabolism has been reinvestigated over the last decades toward identifying various events underlying "how" and "why" a cancer cell employs aerobic glycolysis. Significant progress has been shaped to revise the Warburg effect. In this study, we have integrated the gene expression of 13 different cancer cells with the genome-scale metabolic network of human (. Recon1) based on the E-Flux method, and analyzed them based on constraint-based modeling. Results show that regardless of significant up- and down-regulated metabolic genes, the distribution of metabolic changes is similar in different cancer types. These findings support the theory that the Warburg effect is a consequence of metabolic adaptation in cancer cells.
AB - The Warburg effect means higher glucose uptake of cancer cells compared to normal tissues, whereas a smaller fraction of this glucose is employed for oxidative phosphorylation. With the advent of high throughput technologies and computational systems biology, cancer cell metabolism has been reinvestigated over the last decades toward identifying various events underlying "how" and "why" a cancer cell employs aerobic glycolysis. Significant progress has been shaped to revise the Warburg effect. In this study, we have integrated the gene expression of 13 different cancer cells with the genome-scale metabolic network of human (. Recon1) based on the E-Flux method, and analyzed them based on constraint-based modeling. Results show that regardless of significant up- and down-regulated metabolic genes, the distribution of metabolic changes is similar in different cancer types. These findings support the theory that the Warburg effect is a consequence of metabolic adaptation in cancer cells.
KW - Cancer
KW - Gene expression
KW - Metabolic flux analysis
KW - Metabolic networks
UR - http://www.scopus.com/inward/record.url?scp=84927786144&partnerID=8YFLogxK
U2 - 10.1016/j.ygeno.2015.03.001
DO - 10.1016/j.ygeno.2015.03.001
M3 - Article
C2 - 25773945
AN - SCOPUS:84927786144
SN - 0888-7543
VL - 105
SP - 275
EP - 281
JO - Genomics
JF - Genomics
IS - 5-6
ER -