An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells

Laura Senovilla; Ilio Vitale; Isabelle Martins; Oliver Kepp; Lorenzo Galluzzi; Laurence Zitvoge; Maria Castedo; Guido Kroemer

doi:10.4161/onco.22409

An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells

Laura Senovilla, Ilio Vitale, Isabelle Martins, Oliver Kepp, Lorenzo Galluzzi, Laurence Zitvoge, Maria Castedo, Guido Kroemer

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

22 Citations (Scopus)

Résumé

One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.

langue originale	Anglais
Numéro d'article	e22409
journal	OncoImmunology
Volume	2
Numéro de publication	1
Les DOIs	https://doi.org/10.4161/onco.22409
état	Publié - 1 janv. 2013

Accès au document

10.4161/onco.22409

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title = "An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells",

abstract = "One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.",

keywords = "Breast carcinoma, Calreticulin, HMGB1, Hyperploidy, Immunogenic cell death, Mitotic catastrophe",

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AU - Senovilla, Laura

AU - Vitale, Ilio

AU - Martins, Isabelle

AU - Kepp, Oliver

AU - Galluzzi, Lorenzo

AU - Zitvoge, Laurence

AU - Castedo, Maria

AU - Kroemer, Guido

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N2 - One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.

AB - One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.

KW - Breast carcinoma

KW - Calreticulin

KW - HMGB1

KW - Hyperploidy

KW - Immunogenic cell death

KW - Mitotic catastrophe

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