TY - JOUR
T1 - Analysis of the immune‐encodrine feedback loop in the avian system and its alteration in chickens with spontaneous autoimmune thyroiditis
AU - Brezinschek, Hans P.
AU - Faessler, Reinhard
AU - Klocker, Helmut
AU - Kroemer, Guido
AU - Sgonc, Roswitha
AU - Dietrich, Hermann
AU - Jakober, Rosanna
AU - Wick, Georg
PY - 1990/1/1
Y1 - 1990/1/1
N2 - In both mammals and chickens, immunization with exogenous antigens results in a surge of serum glucocorticoid hormone levels concomitant with the antibody response. This effect is mediated by glucocorticoid‐increasing factors (GIF) produced by cells of the immune system. In the avian system, GIF appear to act via the hypothalamo‐pituitary axis and not directly on the adrenal gland. Interleukin 1 is the main active substance responsible for GIF activity, as shown by molecular sieve and immunoaffinity chromatography studies. In contrast to data from mammals, we found no evidence that interleukin 2 elevates chicken corticosterone. Obese strain chickens with spontaneous Hashimoto‐like autoimmune thyroiditis are deficient in their in vivo GIF response. Because no differences were found between autoimmune and healthy chickens in the corticosterone response of the adrenal gland after ACTH administration, and since autoimmune animals are able to react normally to immobilization stress, it is assumed that this deficiency is due to a specific defect rather than a general disturbance in the endocrine system.
AB - In both mammals and chickens, immunization with exogenous antigens results in a surge of serum glucocorticoid hormone levels concomitant with the antibody response. This effect is mediated by glucocorticoid‐increasing factors (GIF) produced by cells of the immune system. In the avian system, GIF appear to act via the hypothalamo‐pituitary axis and not directly on the adrenal gland. Interleukin 1 is the main active substance responsible for GIF activity, as shown by molecular sieve and immunoaffinity chromatography studies. In contrast to data from mammals, we found no evidence that interleukin 2 elevates chicken corticosterone. Obese strain chickens with spontaneous Hashimoto‐like autoimmune thyroiditis are deficient in their in vivo GIF response. Because no differences were found between autoimmune and healthy chickens in the corticosterone response of the adrenal gland after ACTH administration, and since autoimmune animals are able to react normally to immobilization stress, it is assumed that this deficiency is due to a specific defect rather than a general disturbance in the endocrine system.
UR - http://www.scopus.com/inward/record.url?scp=0025168822&partnerID=8YFLogxK
U2 - 10.1002/eji.1830201002
DO - 10.1002/eji.1830201002
M3 - Article
C2 - 2242753
AN - SCOPUS:0025168822
SN - 0014-2980
VL - 20
SP - 2155
EP - 2159
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 10
ER -