Antigenicity and immunogenicity of the C-terminal peptide of human thyroglobulin

Rabii Ameziane El Hassani, Valérie Estienne, Stéphanie Blanchin, Josée Martine Durand-Gorde, Bernard Mallet, Catherine De Micco, Pierre Carayon, Khalid Lalaoui, Jean Ruf

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    10 Citations (Scopus)

    Résumé

    Thyroglobulin (Tg) is cleaved into several peptides during thyroid hormone synthesis, an oxidative process. P40, an iodinated C-terminal peptide from human Tg, has a molecular weight of about 40 kDa and contains two hormonogenic sites. P40 is the smallest peptide that is still recognized by monoclonal antibodies from mice immunized with human Tg directed against its immunodominant region. Since P40 also contains several T-cell epitopes, it is a good candidate for studying the primary events involved in the process of hormone synthesis leading to thyroid autoimmunity. The present results show that P40 is recognized by Tg antibodies from patients with thyroid disorders and induces Tg antibodies in CBA mice. P40 may therefore be involved in the autoimmune process, thus providing a useful tool for diagnostic and therapeutic purposes.

    langue originaleAnglais
    Pages (de - à)1021-1029
    Nombre de pages9
    journalPeptides
    Volume25
    Numéro de publication6
    Les DOIs
    étatPublié - 1 janv. 2004

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