ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy

Yuting Ma, Sandy Adjemian, Heng Yang, João Paulo Portela Catani, Dalil Hannani, Isabelle Martins, Mickaël Michaud, Oliver Kepp, Abdul Qader Sukkurwala, Erika Vacchelli, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroemer

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    76 Citations (Scopus)

    Résumé

    Tumor cells succumb to chemotherapy while releasing ATP. We have found that extracellular ATP attracts dendritic cell (DC) precursors into the tumor bed, facilitates their permanence in the proximity of dying cells and promotes their differentiation into mature DCs endowed with the capacity of presenting tumor-associated antigens.

    langue originaleAnglais
    Numéro d'articlee24568
    journalOncoImmunology
    Volume2
    Numéro de publication6
    Les DOIs
    étatPublié - 1 juin 2013

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