Autocrine signaling of type 1 interferons in successful anticancer chemotherapy

Erika Vacchelli; Antonella Sistigu; Takahiro Yamazaki; Ilio Vitale; Laurence Zitvogel; Guido Kroemer

doi:10.4161/2162402X.2014.988042

Autocrine signaling of type 1 interferons in successful anticancer chemotherapy

Erika Vacchelli, Antonella Sistigu, Takahiro Yamazaki, Ilio Vitale, Laurence Zitvogel, Guido Kroemer

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

34 Citations (Scopus)

Résumé

Anthracycline-based chemotherapies are particularly effective if they succeed in reinstating immunosurveillance by the induction of immunogenic cell death (ICD) in the tumor. Recently, we discovered that ICD is coupled to the induction of type 1 interferons (IFNs-I) that act in an autocrine fashion on cancer cells, thereby increasing their immunogenic potential.

langue originale	Anglais
journal	OncoImmunology
Volume	4
Numéro de publication	8
Les DOIs	https://doi.org/10.4161/2162402X.2014.988042
état	Publié - 3 août 2015

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10.4161/2162402X.2014.988042

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title = "Autocrine signaling of type 1 interferons in successful anticancer chemotherapy",

abstract = "Anthracycline-based chemotherapies are particularly effective if they succeed in reinstating immunosurveillance by the induction of immunogenic cell death (ICD) in the tumor. Recently, we discovered that ICD is coupled to the induction of type 1 interferons (IFNs-I) that act in an autocrine fashion on cancer cells, thereby increasing their immunogenic potential.",

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AU - Zitvogel, Laurence

AU - Kroemer, Guido

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KW - TLR3

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