TY - JOUR
T1 - Autophagy and aging
AU - Rubinsztein, David C.
AU - Mariño, Guillermo
AU - Kroemer, Guido
N1 - Funding Information:
We apologize to all colleagues whose work we could not cite owing to space limitations. G.K. is supported by the Ligue Nationale contre le Cancer (Equipes labellisée), Agence Nationale pour la Recherche, AXA Chair for Longevity Research, European Commission (Apo-Sys, ArtForce, ChemoRes, ApopTrain), Fondation Bettencourt-Schueller, Fondation pour la Recherche Médicale, the LabEx Immuno-Oncology, Institut National du Cancer, and Cancéropôle Ile-de-France. D.C.R. is supported by the Wellcome Trust (Senior Fellowship), a Wellcome Trust/Medical Research Council Strategic Award on Neurodegenerative Diseases, Medical Research Council, and the National Institute for Health Research Biomedical Research Centre at Addenbrooke's Hospital.
PY - 2011/9/2
Y1 - 2011/9/2
N2 - Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that resemble those associated with aging, and normal and pathological aging are often associated with a reduced autophagic potential. Pharmacological or genetic manipulations that increase life span in model organisms often stimulate autophagy, and its inhibition compromises the longevity-promoting effects of caloric restriction, Sirtuin 1 activation, inhibition of insulin/insulin growth factor signaling, or the administration of rapamycin, resveratrol, or spermidine. Here, we discuss the probable cause and effect relationship between perturbed autophagy and aging, as well as possible molecular mechanisms that may mediate the anti-aging effects of autophagy.
AB - Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that resemble those associated with aging, and normal and pathological aging are often associated with a reduced autophagic potential. Pharmacological or genetic manipulations that increase life span in model organisms often stimulate autophagy, and its inhibition compromises the longevity-promoting effects of caloric restriction, Sirtuin 1 activation, inhibition of insulin/insulin growth factor signaling, or the administration of rapamycin, resveratrol, or spermidine. Here, we discuss the probable cause and effect relationship between perturbed autophagy and aging, as well as possible molecular mechanisms that may mediate the anti-aging effects of autophagy.
UR - http://www.scopus.com/inward/record.url?scp=80052303130&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2011.07.030
DO - 10.1016/j.cell.2011.07.030
M3 - Review article
C2 - 21884931
AN - SCOPUS:80052303130
SN - 0092-8674
VL - 146
SP - 682
EP - 695
JO - Cell
JF - Cell
IS - 5
ER -