Autophagy-dependent ATP release from dying cells via lysosomal exocytosis

Yidan Wang, Isabelle Martins, Yuting Ma, Oliver Kepp, Lorenzo Galluzzi, Guido Kroemer

    Résultats de recherche: Contribution à un journalBrève enquêteRevue par des pairs

    110 Citations (Scopus)

    Résumé

    ATP not only represents a key molecule for the intracellular storage and utilization of energy, but also plays a central role in the extracellular milieu, as it both recruits and activates immune cells. The secretion of ATP in the course of immunogenic cell death (ICD), a peculiar type of apoptosis that elicits adaptive immune responses, critically relies on the molecular machinery for autophagy. We have recently demonstrated that autophagy allows for the ICD-associated secretion of ATP as it contributes to the maintenance of lysosomal ATP stores. In addition, we found that ATP release in this setting is mediated by a molecular mechanism that involves lysosomal-associated membrane protein 1 (LAMP1)- and pannexin 1 (PANX1)-dependent lysosomal exocytosis.

    langue originaleAnglais
    Pages (de - à)1624-1625
    Nombre de pages2
    journalAutophagy
    Volume9
    Numéro de publication10
    Les DOIs
    étatPublié - 1 janv. 2013

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