Autophagy in the Pathogenesis of Disease

Beth Levine; Guido Kroemer

doi:10.1016/j.cell.2007.12.018

Autophagy in the Pathogenesis of Disease

Beth Levine, Guido Kroemer

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

6034 Citations (Scopus)

Résumé

Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation, development, and homeostasis. Autophagy principally serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. However, in certain experimental disease settings, the self-cannibalistic or, paradoxically, even the prosurvival functions of autophagy may be deleterious. This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.

langue originale	Anglais
Pages (de - à)	27-42
Nombre de pages	16
journal	Cell
Volume	132
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/j.cell.2007.12.018
état	Publié - 11 janv. 2008

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10.1016/j.cell.2007.12.018

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title = "Autophagy in the Pathogenesis of Disease",

abstract = "Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation, development, and homeostasis. Autophagy principally serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. However, in certain experimental disease settings, the self-cannibalistic or, paradoxically, even the prosurvival functions of autophagy may be deleterious. This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.",

author = "Beth Levine and Guido Kroemer",

note = "Funding Information: B.L. is supported by the National Institutes of Health, American Cancer Society, and Ellison Medical Foundation. G.K. is supported by Ligue Nationale contre le Cancer, Agence Nationale de Recherche, Institut National contre le Cancer, Canc{\'e}rop{\^o}le Ile-de France, and European Union (Active p53, ApoSys, ChemoRes, DeathTrain, RIGHT, TransDeath). We thank R. Talley for administrative assistance and M. Packer for helpful comments.",

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AU - Kroemer, Guido

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N2 - Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation, development, and homeostasis. Autophagy principally serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. However, in certain experimental disease settings, the self-cannibalistic or, paradoxically, even the prosurvival functions of autophagy may be deleterious. This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.

AB - Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation, development, and homeostasis. Autophagy principally serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. However, in certain experimental disease settings, the self-cannibalistic or, paradoxically, even the prosurvival functions of autophagy may be deleterious. This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.

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