TY - JOUR
T1 - B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization
AU - Angeli, Véronique
AU - Ginhoux, Florent
AU - Llodrà, Jaime
AU - Quemeneur, Laurence
AU - Frenette, Paul S.
AU - Skobe, Mihaela
AU - Jessberger, Rolf
AU - Merad, Miriam
AU - Randolph, Gwendalyn J.
N1 - Funding Information:
We thank Dr. Troy Randall and Dr. Melody Swartz for helpful discussions; Dr. Jon Bromberg for MEL-14 mAb; and Dr. Bronislaw Pytowski and Dr. Daniel J. Hicklin for VEGFR-3 and VEGFR-2 mAbs, respectively. This work was funded by NIH grant HL69446 to G.J.R., a Scientist Development Grant from AHA (National Center) to V.A., and by Emerald Foundation to M.S.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Dendritic cell (DC) migration from the periphery to lymph nodes is regulated by the pattern of genes expressed by DCs themselves and by signals within the surrounding peripheral environment. Here, we report that DC mobilization can also be regulated by signals initiated within the downstream lymph nodes, particularly when lymph nodes enlarge as a consequence of immunization. Lymph node B lymphocytes orchestrate expansion of the lymphatic network within the immunized lymph node. This expanded network in turn supports increased DC migration from the periphery. These results reveal unique relationships between B cells, lymphatic vessels, and migratory DCs. Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination.
AB - Dendritic cell (DC) migration from the periphery to lymph nodes is regulated by the pattern of genes expressed by DCs themselves and by signals within the surrounding peripheral environment. Here, we report that DC mobilization can also be regulated by signals initiated within the downstream lymph nodes, particularly when lymph nodes enlarge as a consequence of immunization. Lymph node B lymphocytes orchestrate expansion of the lymphatic network within the immunized lymph node. This expanded network in turn supports increased DC migration from the periphery. These results reveal unique relationships between B cells, lymphatic vessels, and migratory DCs. Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination.
UR - http://www.scopus.com/inward/record.url?scp=32244443955&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2006.01.003
DO - 10.1016/j.immuni.2006.01.003
M3 - Article
C2 - 16473832
AN - SCOPUS:32244443955
SN - 1074-7613
VL - 24
SP - 203
EP - 215
JO - Immunity
JF - Immunity
IS - 2
ER -