Balancing donor and recipient risk factors in liver transplantation: The value of D-MELD with particular reference to HCV recipients

A. W. Avolio; U. Cillo; M. Salizzoni; L. De Carlis; M. Colledan; G. E. Gerunda; V. Mazzaferro; G. Tisone; R. Romagnoli; L. Caccamo; M. Rossi; A. Vitale; A. Cucchetti; L. Lupo; S. Gruttadauria; N. Nicolotti; P. Burra; A. Gasbarrini; S. Agnes; M. C. Lirosi; L. Miele; M. Pompili; M. Siciliano; V. Perilli; R. Gaspari; M. Castagneto; F. Tandoi; I. Mangoni; L. Belli; A. D. Pinna; M. Cescon; B. Gridelli; S. Li Petri; R. Volpes; S. Fagiuoli; R. Montalti; E. Regalia; B. Antonelli; P. Berloco; Q. Lai; A. Risaliti; D. Nicolini; U. Valente; M. Gelli; N. Morelli; F. Zamboni; V. Tondolo; G. M. Ettorre; G. Vennarecci; F. Bresadola; U. Baccarani; P. L. Toniutto; T. Manzia; A. Anselmo; M. Angelico; F. Calise; V. Scuderi; M. Romano; M. Rendina; M. Barone; O. Cuomo; A. Perrella; W. Santaniello; M. Donataccio; G. Dalle Ore; J. De Ville De Goyet; L. Monti; C. De Waure

doi:10.1111/j.1600-6143.2011.03732.x

Balancing donor and recipient risk factors in liver transplantation: The value of D-MELD with particular reference to HCV recipients

A. W. Avolio, U. Cillo, M. Salizzoni, L. De Carlis, M. Colledan, G. E. Gerunda, V. Mazzaferro, G. Tisone, R. Romagnoli, L. Caccamo, M. Rossi, A. Vitale, A. Cucchetti, L. Lupo, S. Gruttadauria, N. Nicolotti, P. Burra, A. Gasbarrini, S. Agnes, M. C. LirosiL. Miele, M. Pompili, M. Siciliano, V. Perilli, R. Gaspari, M. Castagneto, F. Tandoi, I. Mangoni, L. Belli, A. D. Pinna, M. Cescon, B. Gridelli, S. Li Petri, R. Volpes, S. Fagiuoli, R. Montalti, E. Regalia, B. Antonelli, P. Berloco, Q. Lai, A. Risaliti, D. Nicolini, U. Valente, M. Gelli, N. Morelli, F. Zamboni, V. Tondolo, G. M. Ettorre, G. Vennarecci, F. Bresadola, U. Baccarani, P. L. Toniutto, T. Manzia, A. Anselmo, M. Angelico, F. Calise, V. Scuderi, M. Romano, M. Rendina, M. Barone, O. Cuomo, A. Perrella, W. Santaniello, M. Donataccio, G. Dalle Ore, J. De Ville De Goyet, L. Monti, C. De Waure

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

84 Citations (Scopus)

Résumé

Donor-recipient match is a matter of debate in liver transplantation. D-MELD (donor age x recipient biochemical model for end-stage liver disease [MELD]) and other factors were analyzed on a national Italian database recording 5946 liver transplants. Primary endpoint was to determine factors predictive of 3-year patient survival. D-MELD cutoff predictive of 5-year patient survival <50% (5 yrs PS<50%) was investigated. A prognosis calculator was implemented (www.D-MELD.com). Differences among D-MELD deciles allowed their regrouping into three D-MELD classes (A < 338, B 338-1628, C >1628). At 3 years, the odds ratio (OR) for death was 2.03 (95% confidence interval [CI], 1.44-2.85) in D-MELD class C versus B. The OR was 0.40 (95% CI, 0.24-0.66) in class A versus class B. Other predictors were hepatitis C virus (HCV; OR = 1.42; 95% CI, 1.11-1.81), hepatitis B virus (HBV; OR = 0.69; 95% CI, 0.51-0.93), retransplant (OR = 1.82; 95% CI, 1.16-2.87) and low-volume center (OR = 1.48; 95% CI, 1.11-1.99). Cox regressions up to 90 months confirmed results. The hazard ratio was 1.97 (95% CI, 1.59-2.43) for D-MELD class C versus class B and 0.42 (95% CI, 0.29-0.60) for D-MELD class A versus class B. Recipient age, HCV, HBV and retransplant were also significant. The 5 yrs PS<50% cutoff was identified only in HCV patients (D-MELD ≥ 1750). The innovative approach offered by D-MELD and covariates is helpful in predicting outcome after liver transplantation, especially in HCV recipients.

langue originale	Anglais
Pages (de - à)	2724-2736
Nombre de pages	13
journal	American Journal of Transplantation
Volume	11
Numéro de publication	12
Les DOIs	https://doi.org/10.1111/j.1600-6143.2011.03732.x
état	Publié - 1 déc. 2011
Modification externe	Oui

Accès au document

10.1111/j.1600-6143.2011.03732.x

Autres fichiers et liens

Lien vers la publication dans Scopus

Contient cette citation

Avolio, A. W., Cillo, U., Salizzoni, M., De Carlis, L., Colledan, M., Gerunda, G. E., Mazzaferro, V., Tisone, G., Romagnoli, R., Caccamo, L., Rossi, M., Vitale, A., Cucchetti, A., Lupo, L., Gruttadauria, S., Nicolotti, N., Burra, P., Gasbarrini, A., Agnes, S., ... De Waure, C. (2011). Balancing donor and recipient risk factors in liver transplantation: The value of D-MELD with particular reference to HCV recipients. American Journal of Transplantation, 11(12), 2724-2736. https://doi.org/10.1111/j.1600-6143.2011.03732.x

@article{e149ef179fa54c8b874f0c83f5dd34db,

title = "Balancing donor and recipient risk factors in liver transplantation: The value of D-MELD with particular reference to HCV recipients",

abstract = "Donor-recipient match is a matter of debate in liver transplantation. D-MELD (donor age x recipient biochemical model for end-stage liver disease [MELD]) and other factors were analyzed on a national Italian database recording 5946 liver transplants. Primary endpoint was to determine factors predictive of 3-year patient survival. D-MELD cutoff predictive of 5-year patient survival <50% (5 yrs PS<50%) was investigated. A prognosis calculator was implemented (www.D-MELD.com). Differences among D-MELD deciles allowed their regrouping into three D-MELD classes (A < 338, B 338-1628, C >1628). At 3 years, the odds ratio (OR) for death was 2.03 (95% confidence interval [CI], 1.44-2.85) in D-MELD class C versus B. The OR was 0.40 (95% CI, 0.24-0.66) in class A versus class B. Other predictors were hepatitis C virus (HCV; OR = 1.42; 95% CI, 1.11-1.81), hepatitis B virus (HBV; OR = 0.69; 95% CI, 0.51-0.93), retransplant (OR = 1.82; 95% CI, 1.16-2.87) and low-volume center (OR = 1.48; 95% CI, 1.11-1.99). Cox regressions up to 90 months confirmed results. The hazard ratio was 1.97 (95% CI, 1.59-2.43) for D-MELD class C versus class B and 0.42 (95% CI, 0.29-0.60) for D-MELD class A versus class B. Recipient age, HCV, HBV and retransplant were also significant. The 5 yrs PS<50% cutoff was identified only in HCV patients (D-MELD ≥ 1750). The innovative approach offered by D-MELD and covariates is helpful in predicting outcome after liver transplantation, especially in HCV recipients.",

keywords = "D-MELD, donor-recipient match, liver transplantation, outcome, prognosis, risk factors",

author = "Avolio, {A. W.} and U. Cillo and M. Salizzoni and {De Carlis}, L. and M. Colledan and Gerunda, {G. E.} and V. Mazzaferro and G. Tisone and R. Romagnoli and L. Caccamo and M. Rossi and A. Vitale and A. Cucchetti and L. Lupo and S. Gruttadauria and N. Nicolotti and P. Burra and A. Gasbarrini and S. Agnes and Lirosi, {M. C.} and L. Miele and M. Pompili and M. Siciliano and V. Perilli and R. Gaspari and M. Castagneto and F. Tandoi and I. Mangoni and L. Belli and Pinna, {A. D.} and M. Cescon and B. Gridelli and {Li Petri}, S. and R. Volpes and S. Fagiuoli and R. Montalti and E. Regalia and B. Antonelli and P. Berloco and Q. Lai and A. Risaliti and D. Nicolini and U. Valente and M. Gelli and N. Morelli and F. Zamboni and V. Tondolo and Ettorre, {G. M.} and G. Vennarecci and F. Bresadola and U. Baccarani and Toniutto, {P. L.} and T. Manzia and A. Anselmo and M. Angelico and F. Calise and V. Scuderi and M. Romano and M. Rendina and M. Barone and O. Cuomo and A. Perrella and W. Santaniello and M. Donataccio and {Dalle Ore}, G. and {De Ville De Goyet}, J. and L. Monti and {De Waure}, C.",

year = "2011",

month = dec,

day = "1",

doi = "10.1111/j.1600-6143.2011.03732.x",

language = "English",

volume = "11",

pages = "2724--2736",

journal = "American Journal of Transplantation",

issn = "1600-6135",

number = "12",

}

Avolio, AW, Cillo, U, Salizzoni, M, De Carlis, L, Colledan, M, Gerunda, GE, Mazzaferro, V, Tisone, G, Romagnoli, R, Caccamo, L, Rossi, M, Vitale, A, Cucchetti, A, Lupo, L, Gruttadauria, S, Nicolotti, N, Burra, P, Gasbarrini, A, Agnes, S, Lirosi, MC, Miele, L, Pompili, M, Siciliano, M, Perilli, V, Gaspari, R, Castagneto, M, Tandoi, F, Mangoni, I, Belli, L, Pinna, AD, Cescon, M, Gridelli, B, Li Petri, S, Volpes, R, Fagiuoli, S, Montalti, R, Regalia, E, Antonelli, B, Berloco, P, Lai, Q, Risaliti, A, Nicolini, D, Valente, U, Gelli, M, Morelli, N, Zamboni, F, Tondolo, V, Ettorre, GM, Vennarecci, G, Bresadola, F, Baccarani, U, Toniutto, PL, Manzia, T, Anselmo, A, Angelico, M, Calise, F, Scuderi, V, Romano, M, Rendina, M, Barone, M, Cuomo, O, Perrella, A, Santaniello, W, Donataccio, M, Dalle Ore, G, De Ville De Goyet, J, Monti, L & De Waure, C 2011, 'Balancing donor and recipient risk factors in liver transplantation: The value of D-MELD with particular reference to HCV recipients', American Journal of Transplantation, VOL. 11, Numéro 12, p. 2724-2736. https://doi.org/10.1111/j.1600-6143.2011.03732.x

TY - JOUR

T1 - Balancing donor and recipient risk factors in liver transplantation

T2 - The value of D-MELD with particular reference to HCV recipients

AU - Avolio, A. W.

AU - Cillo, U.

AU - Salizzoni, M.

AU - De Carlis, L.

AU - Colledan, M.

AU - Gerunda, G. E.

AU - Mazzaferro, V.

AU - Tisone, G.

AU - Romagnoli, R.

AU - Caccamo, L.

AU - Rossi, M.

AU - Vitale, A.

AU - Cucchetti, A.

AU - Lupo, L.

AU - Gruttadauria, S.

AU - Nicolotti, N.

AU - Burra, P.

AU - Gasbarrini, A.

AU - Agnes, S.

AU - Lirosi, M. C.

AU - Miele, L.

AU - Pompili, M.

AU - Siciliano, M.

AU - Perilli, V.

AU - Gaspari, R.

AU - Castagneto, M.

AU - Tandoi, F.

AU - Mangoni, I.

AU - Belli, L.

AU - Pinna, A. D.

AU - Cescon, M.

AU - Gridelli, B.

AU - Li Petri, S.

AU - Volpes, R.

AU - Fagiuoli, S.

AU - Montalti, R.

AU - Regalia, E.

AU - Antonelli, B.

AU - Berloco, P.

AU - Lai, Q.

AU - Risaliti, A.

AU - Nicolini, D.

AU - Valente, U.

AU - Gelli, M.

AU - Morelli, N.

AU - Zamboni, F.

AU - Tondolo, V.

AU - Ettorre, G. M.

AU - Vennarecci, G.

AU - Bresadola, F.

AU - Baccarani, U.

AU - Toniutto, P. L.

AU - Manzia, T.

AU - Anselmo, A.

AU - Angelico, M.

AU - Calise, F.

AU - Scuderi, V.

AU - Romano, M.

AU - Rendina, M.

AU - Barone, M.

AU - Cuomo, O.

AU - Perrella, A.

AU - Santaniello, W.

AU - Donataccio, M.

AU - Dalle Ore, G.

AU - De Ville De Goyet, J.

AU - Monti, L.

AU - De Waure, C.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Donor-recipient match is a matter of debate in liver transplantation. D-MELD (donor age x recipient biochemical model for end-stage liver disease [MELD]) and other factors were analyzed on a national Italian database recording 5946 liver transplants. Primary endpoint was to determine factors predictive of 3-year patient survival. D-MELD cutoff predictive of 5-year patient survival <50% (5 yrs PS<50%) was investigated. A prognosis calculator was implemented (www.D-MELD.com). Differences among D-MELD deciles allowed their regrouping into three D-MELD classes (A < 338, B 338-1628, C >1628). At 3 years, the odds ratio (OR) for death was 2.03 (95% confidence interval [CI], 1.44-2.85) in D-MELD class C versus B. The OR was 0.40 (95% CI, 0.24-0.66) in class A versus class B. Other predictors were hepatitis C virus (HCV; OR = 1.42; 95% CI, 1.11-1.81), hepatitis B virus (HBV; OR = 0.69; 95% CI, 0.51-0.93), retransplant (OR = 1.82; 95% CI, 1.16-2.87) and low-volume center (OR = 1.48; 95% CI, 1.11-1.99). Cox regressions up to 90 months confirmed results. The hazard ratio was 1.97 (95% CI, 1.59-2.43) for D-MELD class C versus class B and 0.42 (95% CI, 0.29-0.60) for D-MELD class A versus class B. Recipient age, HCV, HBV and retransplant were also significant. The 5 yrs PS<50% cutoff was identified only in HCV patients (D-MELD ≥ 1750). The innovative approach offered by D-MELD and covariates is helpful in predicting outcome after liver transplantation, especially in HCV recipients.

AB - Donor-recipient match is a matter of debate in liver transplantation. D-MELD (donor age x recipient biochemical model for end-stage liver disease [MELD]) and other factors were analyzed on a national Italian database recording 5946 liver transplants. Primary endpoint was to determine factors predictive of 3-year patient survival. D-MELD cutoff predictive of 5-year patient survival <50% (5 yrs PS<50%) was investigated. A prognosis calculator was implemented (www.D-MELD.com). Differences among D-MELD deciles allowed their regrouping into three D-MELD classes (A < 338, B 338-1628, C >1628). At 3 years, the odds ratio (OR) for death was 2.03 (95% confidence interval [CI], 1.44-2.85) in D-MELD class C versus B. The OR was 0.40 (95% CI, 0.24-0.66) in class A versus class B. Other predictors were hepatitis C virus (HCV; OR = 1.42; 95% CI, 1.11-1.81), hepatitis B virus (HBV; OR = 0.69; 95% CI, 0.51-0.93), retransplant (OR = 1.82; 95% CI, 1.16-2.87) and low-volume center (OR = 1.48; 95% CI, 1.11-1.99). Cox regressions up to 90 months confirmed results. The hazard ratio was 1.97 (95% CI, 1.59-2.43) for D-MELD class C versus class B and 0.42 (95% CI, 0.29-0.60) for D-MELD class A versus class B. Recipient age, HCV, HBV and retransplant were also significant. The 5 yrs PS<50% cutoff was identified only in HCV patients (D-MELD ≥ 1750). The innovative approach offered by D-MELD and covariates is helpful in predicting outcome after liver transplantation, especially in HCV recipients.

KW - D-MELD

KW - donor-recipient match

KW - liver transplantation

KW - outcome

KW - prognosis

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=82455212065&partnerID=8YFLogxK

U2 - 10.1111/j.1600-6143.2011.03732.x

DO - 10.1111/j.1600-6143.2011.03732.x

M3 - Article

AN - SCOPUS:82455212065

SN - 1600-6135

VL - 11

SP - 2724

EP - 2736

JO - American Journal of Transplantation

JF - American Journal of Transplantation

IS - 12

ER -