Beclin 1: A BH3-only protein that fails to induce apoptosis

P. Boya; G. Kroemer

doi:10.1038/onc.2009.83

Beclin 1: A BH3-only protein that fails to induce apoptosis

P. Boya, G. Kroemer

Résultats de recherche: Contribution à un journal › !!Comment/debate

31 Citations (Scopus)

Résumé

Beclin 1 has been recently shown to possess a Bcl-2 homology-3 (BH3) domain that mediates its interaction with antiapoptotic multidomain proteins. Unlike other BH3-only proteins, Beclin 1 fails to stimulate apoptosis when it is overexpressed. In this issue of Oncogene, Ciechomska et al. report the intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential. This finding may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagy.

langue originale	Anglais
Pages (de - à)	2125-2127
Nombre de pages	3
journal	Oncogene
Volume	28
Numéro de publication	21
Les DOIs	https://doi.org/10.1038/onc.2009.83
état	Publié - 28 mai 2009

Accès au document

10.1038/onc.2009.83

Autres fichiers et liens

Lien vers la publication dans Scopus

Contient cette citation

@article{ef027b4f215a49edbfb4bc4e9276477d,

title = "Beclin 1: A BH3-only protein that fails to induce apoptosis",

abstract = "Beclin 1 has been recently shown to possess a Bcl-2 homology-3 (BH3) domain that mediates its interaction with antiapoptotic multidomain proteins. Unlike other BH3-only proteins, Beclin 1 fails to stimulate apoptosis when it is overexpressed. In this issue of Oncogene, Ciechomska et al. report the intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential. This finding may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagy.",

keywords = "Autophagy; apoptosis; Bcl-2, Beclin-1; endoplasmic reticulum; mitochondria",

author = "P. Boya and G. Kroemer",

year = "2009",

month = may,

day = "28",

doi = "10.1038/onc.2009.83",

language = "English",

volume = "28",

pages = "2125--2127",

journal = "Oncogene",

issn = "0950-9232",

number = "21",

}

TY - JOUR

T1 - Beclin 1

T2 - A BH3-only protein that fails to induce apoptosis

AU - Boya, P.

AU - Kroemer, G.

PY - 2009/5/28

Y1 - 2009/5/28

N2 - Beclin 1 has been recently shown to possess a Bcl-2 homology-3 (BH3) domain that mediates its interaction with antiapoptotic multidomain proteins. Unlike other BH3-only proteins, Beclin 1 fails to stimulate apoptosis when it is overexpressed. In this issue of Oncogene, Ciechomska et al. report the intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential. This finding may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagy.

AB - Beclin 1 has been recently shown to possess a Bcl-2 homology-3 (BH3) domain that mediates its interaction with antiapoptotic multidomain proteins. Unlike other BH3-only proteins, Beclin 1 fails to stimulate apoptosis when it is overexpressed. In this issue of Oncogene, Ciechomska et al. report the intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential. This finding may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagy.

KW - Autophagy; apoptosis; Bcl-2, Beclin-1; endoplasmic reticulum; mitochondria

UR - http://www.scopus.com/inward/record.url?scp=67349171677&partnerID=8YFLogxK

U2 - 10.1038/onc.2009.83

DO - 10.1038/onc.2009.83

M3 - Comment/debate

C2 - 19398951

AN - SCOPUS:67349171677

SN - 0950-9232

VL - 28

SP - 2125

EP - 2127

JO - Oncogene

JF - Oncogene

IS - 21

ER -