Better understanding tumor-host interaction in head and neck cancer to improve the design and development of immunotherapeutic strategies

Cécile Badoual, Federico Sandoval, Helene Pere, Stephane Hans, Alain Gey, Nathalie Merillon, Cordelia Van Ryswick, Françoise Quintin-Colonna, Patrick Bruneval, Daniel Brasnu, Wolf H. Fridman, Eric Tartour

Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

50 Citations (Scopus)

Résumé

Head and neck cancers are heavily infiltrated by immune cells, the significance of which is complex. The natural immune response against head and neck tumors, including antihuman papillomavirus (HPV) T cells, and humoral responses has been clearly documented. However, during the course of tumor progression, co-option of the immune system by tumor cells for their own advantage and increased resistance of tumor cells to immune attack also occur. Inflammation and immune subversion to support angiogenesis are key factors promoting tumor growth. Only a better understanding of this tumor-host interaction will permit a rational design of new immunotherapeutic approaches combining immunostimulation with drugs endowed with the ability to counteract immunoevasion mechanisms.

langue originaleAnglais
Pages (de - à)946-958
Nombre de pages13
journalHead and Neck
Volume32
Numéro de publication7
Les DOIs
étatPublié - 1 juil. 2010
Modification externeOui

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