Beyond first-line systemic treatment for metastatic urothelial carcinoma of the bladder

E. El Rassy, T. Assi, Z. Bakouny, N. Pavlidis, J. Kattan

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    7 Citations (Scopus)

    Résumé

    Metastatic urothelial carcinoma of the bladder is a rarely curable disease. Patients receive systemic therapy with limited response rates and survival benefits. The rescue regimens of these patients who have failed first-line treatment had remained problematic until the recent advances. Several trials with novel regimens, including immune checkpoint inhibitors and targeted therapy, to salvage relapsed urothelial carcinoma of the bladder have recently been published. However, the choice of an optimal treatment regimen remains challenging in the absence of randomized trials comparing regimen sequences. Daily clinical cases provoke the question of whether there is a preferred second-line regimen. This paper provides an overview of recent trials and proposes a management algorithm based on subgroup analyses and prognostic features.

    langue originaleAnglais
    Pages (de - à)280-288
    Nombre de pages9
    journalClinical and Translational Oncology
    Volume21
    Numéro de publication3
    Les DOIs
    étatPublié - 8 mars 2019

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