Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance

Marine Fidelle, Ai Ling Tian, Laurence Zitvogel, Guido Kroemer

    Résultats de recherche: Contribution à un journalEditorial

    3 Citations (Scopus)

    Résumé

    In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gut-associated lymphoid tissues toward tumors.

    langue originaleAnglais
    Numéro d'article2224672
    journalOncoImmunology
    Volume12
    Numéro de publication1
    Les DOIs
    étatPublié - 1 janv. 2023

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