Biological Investigation of a Water-Soluble Isoginkgetin-Phosphate Analogue, Targeting the Spliceosome with In Vivo Antitumor Activity

Boris Letribot, Megane Nascimento, Giulia Cerrato, Romain Darrigrand, Valerie Salgues, Dolor Renko, Alain Pruvost, Mouad Alami, Samir Messaoudi, Sebastien Apcher

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    4 Citations (Scopus)

    Résumé

    The first total synthesis of the natural product Isoginkgetin as well as four water-soluble Isoginkgetin-phosphate analogues is reported herein. Moreover, the full study of the IP2 phosphate analogue with respect to pharmacological properties (metabolic and plasmatic stabilities, pharmacokinetic, off-target, etc.) as well as in vitro and in vivo biological activities are disclosed herein.

    langue originaleAnglais
    Pages (de - à)4633-4648
    Nombre de pages16
    journalJournal of Medicinal Chemistry
    Volume65
    Numéro de publication6
    Les DOIs
    étatPublié - 24 mars 2022

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