TY - JOUR
T1 - Biomarker Discovery and Validation
T2 - Statistical Considerations
AU - Ou, Fang Shu
AU - Michiels, Stefan
AU - Shyr, Yu
AU - Adjei, Alex A.
AU - Oberg, Ann L.
N1 - Publisher Copyright:
© 2021 International Association for the Study of Lung Cancer
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Biomarkers have various applications including disease detection, diagnosis, prognosis, prediction of response to intervention, and disease monitoring. In this era of precision medicine, having validated biomarkers to inform clinical decision making is more important than ever. In this article, we discuss best the practices and potential issues in biomarker discovery and validation. We encourage team science partnerships to bring cutting-edge discovery from bench to bedside, leading to improved patient care and outcomes.
AB - Biomarkers have various applications including disease detection, diagnosis, prognosis, prediction of response to intervention, and disease monitoring. In this era of precision medicine, having validated biomarkers to inform clinical decision making is more important than ever. In this article, we discuss best the practices and potential issues in biomarker discovery and validation. We encourage team science partnerships to bring cutting-edge discovery from bench to bedside, leading to improved patient care and outcomes.
KW - Biomarker
KW - Clinical trial
KW - Confirmation analysis
KW - Exploratory analysis
UR - http://www.scopus.com/inward/record.url?scp=85101357100&partnerID=8YFLogxK
U2 - 10.1016/j.jtho.2021.01.1616
DO - 10.1016/j.jtho.2021.01.1616
M3 - Article
C2 - 33545385
AN - SCOPUS:85101357100
SN - 1556-0864
VL - 16
SP - 537
EP - 545
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
IS - 4
ER -