Body surface area-based dosing regimen of caspofungin in children: A population pharmacokinetics confirmatory study

Xin Mei Yang; Stephanie Leroux; Thomas Storme; Dao Lun Zhang; Tiphaine Adam de Beaumais; Hai Yan Shi; Yi Lei Yang; Xiao Ling Wang; Wei Zhao; Evelyne Jacqz-Aigrain

doi:10.1128/AAC.00248-19

Body surface area-based dosing regimen of caspofungin in children: A population pharmacokinetics confirmatory study

Xin Mei Yang, Stephanie Leroux, Thomas Storme, Dao Lun Zhang, Tiphaine Adam de Beaumais, Hai Yan Shi, Yi Lei Yang, Xiao Ling Wang, Wei Zhao, Evelyne Jacqz-Aigrain

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

10 Citations (Scopus)

Résumé

We evaluated the population pharmacokinetics of caspofungin in children (2 to 12 years of age). The real-world data from 48 children were best fit by a two-compartment model with first-order elimination. Subsequent covariate analysis demonstrated that body surface area had a significant correlation with caspofungin pharmacokinetics, compared to body weight. The population pharmacokinetics of caspofungin confirmed that adjustment of caspofungin dosage based on body surface area is most appropriate for pediatric use.

langue originale	Anglais
Numéro d'article	e00248-19
journal	Antimicrobial Agents and Chemotherapy
Volume	63
Numéro de publication	7
Les DOIs	https://doi.org/10.1128/AAC.00248-19
état	Publié - 1 janv. 2019

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10.1128/AAC.00248-19

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title = "Body surface area-based dosing regimen of caspofungin in children: A population pharmacokinetics confirmatory study",

abstract = "We evaluated the population pharmacokinetics of caspofungin in children (2 to 12 years of age). The real-world data from 48 children were best fit by a two-compartment model with first-order elimination. Subsequent covariate analysis demonstrated that body surface area had a significant correlation with caspofungin pharmacokinetics, compared to body weight. The population pharmacokinetics of caspofungin confirmed that adjustment of caspofungin dosage based on body surface area is most appropriate for pediatric use.",

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T2 - A population pharmacokinetics confirmatory study

AU - Yang, Xin Mei

AU - Leroux, Stephanie

AU - Storme, Thomas

AU - Zhang, Dao Lun

AU - Adam de Beaumais, Tiphaine

AU - Shi, Hai Yan

AU - Yang, Yi Lei

AU - Wang, Xiao Ling

AU - Zhao, Wei

AU - Jacqz-Aigrain, Evelyne

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AB - We evaluated the population pharmacokinetics of caspofungin in children (2 to 12 years of age). The real-world data from 48 children were best fit by a two-compartment model with first-order elimination. Subsequent covariate analysis demonstrated that body surface area had a significant correlation with caspofungin pharmacokinetics, compared to body weight. The population pharmacokinetics of caspofungin confirmed that adjustment of caspofungin dosage based on body surface area is most appropriate for pediatric use.

KW - Caspofungin

KW - Children

KW - Developmental pharmacokinetics

KW - Dose

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