TY - JOUR
T1 - Breast cancer subtype of French women is not influenced by socioeconomic status
T2 - A population-based-study
AU - Auguste, Aviane
AU - Cortet, Marion
AU - Dabakuyo-Yonli, Tienhan Sandrine
AU - Launay, Ludivine
AU - Arnould, Laurent
AU - Desmoulins, Isabelle
AU - Roignot, Patrick
AU - Darut-Jouve, Ariane
AU - Poillot, Marie Laure
AU - Bertaut, Auré Lie
AU - Arveux, Patrick
N1 - Publisher Copyright:
© 2017 Auguste et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Context: The molecular subtype of breast tumours plays a major role in cancer prognosis and treatment options. Triple negative tumours (TN) carry the worst prognosis and affects most frequently women of low socioeconomic status (SES). Studies have shown that non-biologic factors, such as the socioeconomic status could have an influence on tumour biology. To this date no study has been done investigating this association in French women. The objective is to study the association between the SES and the molecular tumour subtype of breast cancer patients in the French county of Cóte d'Or. This study benefits from the population data from the Cóte d'Or breast cancer registry known for its strict quality control policy. Methods: Invasive breast cancer cases between 2003 and 2013 were extracted from the Breast cancer registry database in Cóte d'Or. A multivariate analysis was conducted using a hierarchical polytomous regression for the multinomial outcomes for the cancer subtype with HR +/HER2 as reference category. Results: A total of 4553 cases were included in our study. There was no significant association found between SES and tumour subtype in French women at diagnosis. Women older than 75 years were less likely to have a TN and HR+/HER2+ breast cancer (OR = 0.66; CI95% = [0.46-0.94] and OR = 0.51; CI95% = [0.37-0.70] respectively). Women with TN tumour subtype had significantly less lymph node invasion when compared to HR+/HER2-subtype (OR = 0.71; CI95% = [0.54-0.92]). Conclusion: No significant association was found between socioeconomic status and molecular subtype. Further studies are needed to clarify the mechanisms associated with developing each tumour subtype.
AB - Context: The molecular subtype of breast tumours plays a major role in cancer prognosis and treatment options. Triple negative tumours (TN) carry the worst prognosis and affects most frequently women of low socioeconomic status (SES). Studies have shown that non-biologic factors, such as the socioeconomic status could have an influence on tumour biology. To this date no study has been done investigating this association in French women. The objective is to study the association between the SES and the molecular tumour subtype of breast cancer patients in the French county of Cóte d'Or. This study benefits from the population data from the Cóte d'Or breast cancer registry known for its strict quality control policy. Methods: Invasive breast cancer cases between 2003 and 2013 were extracted from the Breast cancer registry database in Cóte d'Or. A multivariate analysis was conducted using a hierarchical polytomous regression for the multinomial outcomes for the cancer subtype with HR +/HER2 as reference category. Results: A total of 4553 cases were included in our study. There was no significant association found between SES and tumour subtype in French women at diagnosis. Women older than 75 years were less likely to have a TN and HR+/HER2+ breast cancer (OR = 0.66; CI95% = [0.46-0.94] and OR = 0.51; CI95% = [0.37-0.70] respectively). Women with TN tumour subtype had significantly less lymph node invasion when compared to HR+/HER2-subtype (OR = 0.71; CI95% = [0.54-0.92]). Conclusion: No significant association was found between socioeconomic status and molecular subtype. Further studies are needed to clarify the mechanisms associated with developing each tumour subtype.
UR - http://www.scopus.com/inward/record.url?scp=85012996400&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0170069
DO - 10.1371/journal.pone.0170069
M3 - Article
C2 - 28199325
AN - SCOPUS:85012996400
SN - 1932-6203
VL - 12
JO - PLoS ONE
JF - PLoS ONE
IS - 2
M1 - e0170069
ER -