Brief Report: Real-World Clinical Utility of Next-Generation Sequencing of Circulating Tumor DNA for Patients With Advanced Lung Squamous Cell Carcinoma (SQUIN)

Miguel García-Pardo; Marta García de Herreros; Juan Carlos Laguna; Teresa Gorría; Yolanda Lage; Ana Gómez; Mª Eugenia Olmedo; Pilar Garrido; Víctor Manuel Albarran-Artahona; Ainara Arcocha; Cristina Teixido; Noemí Reguart; Alejandro Navarro; Edouard Auclin; Mike S. Nahorski; Karen Howarth; David Planchard; Benjamin Besse; Natasha B. Leighl; Laura Mezquita

doi:10.1016/j.cllc.2025.02.007

Brief Report: Real-World Clinical Utility of Next-Generation Sequencing of Circulating Tumor DNA for Patients With Advanced Lung Squamous Cell Carcinoma (SQUIN)

Miguel García-Pardo, Marta García de Herreros, Juan Carlos Laguna, Teresa Gorría, Yolanda Lage, Ana Gómez, Mª Eugenia Olmedo, Pilar Garrido, Víctor Manuel Albarran-Artahona, Ainara Arcocha, Cristina Teixido, Noemí Reguart, Alejandro Navarro, Edouard Auclin, Mike S. Nahorski, Karen Howarth, David Planchard, Benjamin Besse, Natasha B. Leighl, Laura Mezquita

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

• Plasma-based next generation sequencing (NGS) can identify clinically informative results in a meaningful proportion of patients with lung squamous cell carcinoma. • ESMO ESCAT tier I genomic alterations (ready for routine use; alteration-drug match associated with improved outcome in clinical trials) were found in 4% of patients. • Routine comprehensive molecular profiling, including plasma ctDNA NGS testing, may be considered in patients with lung squamous cell carcinoma.

langue originale	Anglais
journal	Clinical Lung Cancer
Les DOIs	https://doi.org/10.1016/j.cllc.2025.02.007
état	Accepté/sous presse - 1 janv. 2025

Accès au document

10.1016/j.cllc.2025.02.007

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García-Pardo, M., García de Herreros, M., Laguna, J. C., Gorría, T., Lage, Y., Gómez, A., Olmedo, M. E., Garrido, P., Albarran-Artahona, V. M., Arcocha, A., Teixido, C., Reguart, N., Navarro, A., Auclin, E., Nahorski, M. S., Howarth, K., Planchard, D., Besse, B., Leighl, N. B., & Mezquita, L. (Accepté/en presse). Brief Report: Real-World Clinical Utility of Next-Generation Sequencing of Circulating Tumor DNA for Patients With Advanced Lung Squamous Cell Carcinoma (SQUIN). Clinical Lung Cancer. https://doi.org/10.1016/j.cllc.2025.02.007

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title = "Brief Report: Real-World Clinical Utility of Next-Generation Sequencing of Circulating Tumor DNA for Patients With Advanced Lung Squamous Cell Carcinoma (SQUIN)",

abstract = "• Plasma-based next generation sequencing (NGS) can identify clinically informative results in a meaningful proportion of patients with lung squamous cell carcinoma. • ESMO ESCAT tier I genomic alterations (ready for routine use; alteration-drug match associated with improved outcome in clinical trials) were found in 4% of patients. • Routine comprehensive molecular profiling, including plasma ctDNA NGS testing, may be considered in patients with lung squamous cell carcinoma.",

keywords = "ESMO ESCAT, Liquid biopsy, NGS, NSCLC, ctDNA",

author = "Miguel Garc{\'i}a-Pardo and {Garc{\'i}a de Herreros}, Marta and Laguna, {Juan Carlos} and Teresa Gorr{\'i}a and Yolanda Lage and Ana G{\'o}mez and Olmedo, {Mª Eugenia} and Pilar Garrido and Albarran-Artahona, {V{\'i}ctor Manuel} and Ainara Arcocha and Cristina Teixido and Noem{\'i} Reguart and Alejandro Navarro and Edouard Auclin and Nahorski, {Mike S.} and Karen Howarth and David Planchard and Benjamin Besse and Leighl, {Natasha B.} and Laura Mezquita",

note = "Publisher Copyright: {\textcopyright} 2025",

year = "2025",

month = jan,

day = "1",

doi = "10.1016/j.cllc.2025.02.007",

language = "English",

journal = "Clinical Lung Cancer",

issn = "1525-7304",

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García-Pardo, M, García de Herreros, M, Laguna, JC, Gorría, T, Lage, Y, Gómez, A, Olmedo, ME, Garrido, P, Albarran-Artahona, VM, Arcocha, A, Teixido, C, Reguart, N, Navarro, A, Auclin, E, Nahorski, MS, Howarth, K, Planchard, D, Besse, B, Leighl, NB & Mezquita, L 2025, 'Brief Report: Real-World Clinical Utility of Next-Generation Sequencing of Circulating Tumor DNA for Patients With Advanced Lung Squamous Cell Carcinoma (SQUIN)', Clinical Lung Cancer. https://doi.org/10.1016/j.cllc.2025.02.007

TY - JOUR

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T2 - Real-World Clinical Utility of Next-Generation Sequencing of Circulating Tumor DNA for Patients With Advanced Lung Squamous Cell Carcinoma (SQUIN)

AU - García-Pardo, Miguel

AU - García de Herreros, Marta

AU - Laguna, Juan Carlos

AU - Gorría, Teresa

AU - Lage, Yolanda

AU - Gómez, Ana

AU - Olmedo, Mª Eugenia

AU - Garrido, Pilar

AU - Albarran-Artahona, Víctor Manuel

AU - Arcocha, Ainara

AU - Teixido, Cristina

AU - Reguart, Noemí

AU - Navarro, Alejandro

AU - Auclin, Edouard

AU - Nahorski, Mike S.

AU - Howarth, Karen

AU - Planchard, David

AU - Besse, Benjamin

AU - Leighl, Natasha B.

AU - Mezquita, Laura

PY - 2025/1/1

Y1 - 2025/1/1

N2 - • Plasma-based next generation sequencing (NGS) can identify clinically informative results in a meaningful proportion of patients with lung squamous cell carcinoma. • ESMO ESCAT tier I genomic alterations (ready for routine use; alteration-drug match associated with improved outcome in clinical trials) were found in 4% of patients. • Routine comprehensive molecular profiling, including plasma ctDNA NGS testing, may be considered in patients with lung squamous cell carcinoma.

AB - • Plasma-based next generation sequencing (NGS) can identify clinically informative results in a meaningful proportion of patients with lung squamous cell carcinoma. • ESMO ESCAT tier I genomic alterations (ready for routine use; alteration-drug match associated with improved outcome in clinical trials) were found in 4% of patients. • Routine comprehensive molecular profiling, including plasma ctDNA NGS testing, may be considered in patients with lung squamous cell carcinoma.

KW - ESMO ESCAT

KW - Liquid biopsy

KW - NGS

KW - NSCLC

KW - ctDNA

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