Bypass the cancer resistance to immunotherapy: Gut microbiota-based therapeutic interventions

M. Fidelle; L. Derosa; B. Routy; L. Zitvogel

doi:10.1016/j.banm.2021.01.022

Bypass the cancer resistance to immunotherapy: Gut microbiota-based therapeutic interventions

Titre traduit de la contribution: Contourner la résistance à l'immunothérapie des cancers: interventions centrées sur le microbiome intestinal

M. Fidelle, L. Derosa, B. Routy, L. Zitvogel

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

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Résumé

An increasing number of preclinical and clinical studies highlight the tremendous impact of the taxonomic composition of the gut microbiota on anticancer treatments, such as, chemotherapy, radiotherapy and immunotherapy. Recently, causatives interactions between some bacteria or their phage and innate or adaptive immune responses have been discovered. Understand the crosstalk between the gut and the tumor microenvironment opens up a new therapeutic field in gut microbiota modulation. This review resumes the immunomodulation generated by the microbiota, the deleterious impact of the antibiotics on this system and new therapeutic interventions studied in human clinical trials.

Titre traduit de la contribution	Contourner la résistance à l'immunothérapie des cancers: interventions centrées sur le microbiome intestinal
langue originale	Anglais
Pages (de - à)	364-382
Nombre de pages	19
journal	Bulletin de l'Academie Nationale de Medecine
Volume	205
Numéro de publication	4
Les DOIs	https://doi.org/10.1016/j.banm.2021.01.022
état	Publié - 1 avr. 2021

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10.1016/j.banm.2021.01.022

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title = "Bypass the cancer resistance to immunotherapy: Gut microbiota-based therapeutic interventions",

abstract = "An increasing number of preclinical and clinical studies highlight the tremendous impact of the taxonomic composition of the gut microbiota on anticancer treatments, such as, chemotherapy, radiotherapy and immunotherapy. Recently, causatives interactions between some bacteria or their phage and innate or adaptive immune responses have been discovered. Understand the crosstalk between the gut and the tumor microenvironment opens up a new therapeutic field in gut microbiota modulation. This review resumes the immunomodulation generated by the microbiota, the deleterious impact of the antibiotics on this system and new therapeutic interventions studied in human clinical trials.",

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AU - Fidelle, M.

AU - Derosa, L.

AU - Routy, B.

AU - Zitvogel, L.

PY - 2021/4/1

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KW - Antibiotiques antinéoplasiques

KW - Antibodies

KW - Anticorps antitumoraux

KW - Antineoplastic

KW - Immunotherapy

KW - Immunothérapie

KW - Microbiota

KW - Microbiote

KW - Neoplasm

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JO - Bulletin de l'Academie Nationale de Medecine

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