C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

Guillaume Hoeffel; Jinmiao Chen; Yonit Lavin; Donovan Low; Francisca F. Almeida; Peter See; Anna E. Beaudin; Josephine Lum; Ivy Low; E. Camilla Forsberg; Michael Poidinger; Francesca Zolezzi; Anis Larbi; Lai Guan Ng; Jerry K.Y. Chan; Melanie Greter; Burkhard Becher; Igor M. Samokhvalov; Miriam Merad; Florent Ginhoux

doi:10.1016/j.immuni.2015.03.011

C-Myb⁺ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

Guillaume Hoeffel, Jinmiao Chen, Yonit Lavin, Donovan Low, Francisca F. Almeida, Peter See, Anna E. Beaudin, Josephine Lum, Ivy Low, E. Camilla Forsberg, Michael Poidinger, Francesca Zolezzi, Anis Larbi, Lai Guan Ng, Jerry K.Y. Chan, Melanie Greter, Burkhard Becher, Igor M. Samokhvalov, Miriam Merad, Florent Ginhoux

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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Résumé

Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth togenerate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fate-mapping of yolk sac (YS) and fetal liver (FL) hematopoiesis. We show that YS MFs are the main precursors of microglia, while most other MFs derive from fetal monocytes (MOs). Both YS MFs and fetal MOs arise from erythro-myeloid progenitors (EMPs) generated in the YS. In the YS, EMPs gave rise to MFs without monocytic intermediates, while EMP seeding the FL upon the establishment of blood circulation acquired c-Myb expression and gave rise to fetal MOs that then seeded embryonic tissues and differentiated into MFs. Thus, adult tissue-resident MFs established from hematopoietic stem cell-independent embryonic precursors arise from two distinct developmental programs.

langue originale	Anglais
Pages (de - à)	665-678
Nombre de pages	14
journal	Immunity
Volume	42
Numéro de publication	4
Les DOIs	https://doi.org/10.1016/j.immuni.2015.03.011
état	Publié - 21 avr. 2015
Modification externe	Oui

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10.1016/j.immuni.2015.03.011

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Hoeffel, G., Chen, J., Lavin, Y., Low, D., Almeida, F. F., See, P., Beaudin, A. E., Lum, J., Low, I., Forsberg, E. C., Poidinger, M., Zolezzi, F., Larbi, A., Ng, L. G., Chan, J. K. Y., Greter, M., Becher, B., Samokhvalov, I. M., Merad, M., & Ginhoux, F. (2015). C-Myb⁺ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages. Immunity, 42(4), 665-678. https://doi.org/10.1016/j.immuni.2015.03.011

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title = "C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages",

abstract = "Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth togenerate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fate-mapping of yolk sac (YS) and fetal liver (FL) hematopoiesis. We show that YS MFs are the main precursors of microglia, while most other MFs derive from fetal monocytes (MOs). Both YS MFs and fetal MOs arise from erythro-myeloid progenitors (EMPs) generated in the YS. In the YS, EMPs gave rise to MFs without monocytic intermediates, while EMP seeding the FL upon the establishment of blood circulation acquired c-Myb expression and gave rise to fetal MOs that then seeded embryonic tissues and differentiated into MFs. Thus, adult tissue-resident MFs established from hematopoietic stem cell-independent embryonic precursors arise from two distinct developmental programs.",

author = "Guillaume Hoeffel and Jinmiao Chen and Yonit Lavin and Donovan Low and Almeida, {Francisca F.} and Peter See and Beaudin, {Anna E.} and Josephine Lum and Ivy Low and Forsberg, {E. Camilla} and Michael Poidinger and Francesca Zolezzi and Anis Larbi and Ng, {Lai Guan} and Chan, {Jerry K.Y.} and Melanie Greter and Burkhard Becher and Samokhvalov, {Igor M.} and Miriam Merad and Florent Ginhoux",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = apr,

day = "21",

doi = "10.1016/j.immuni.2015.03.011",

language = "English",

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Hoeffel, G, Chen, J, Lavin, Y, Low, D, Almeida, FF, See, P, Beaudin, AE, Lum, J, Low, I, Forsberg, EC, Poidinger, M, Zolezzi, F, Larbi, A, Ng, LG, Chan, JKY, Greter, M, Becher, B, Samokhvalov, IM, Merad, M & Ginhoux, F 2015, 'C-Myb⁺ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages', Immunity, VOL. 42, Numéro 4, p. 665-678. https://doi.org/10.1016/j.immuni.2015.03.011

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T1 - C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

AU - Hoeffel, Guillaume

AU - Chen, Jinmiao

AU - Lavin, Yonit

AU - Low, Donovan

AU - Almeida, Francisca F.

AU - See, Peter

AU - Beaudin, Anna E.

AU - Lum, Josephine

AU - Low, Ivy

AU - Forsberg, E. Camilla

AU - Poidinger, Michael

AU - Zolezzi, Francesca

AU - Larbi, Anis

AU - Ng, Lai Guan

AU - Chan, Jerry K.Y.

AU - Greter, Melanie

AU - Becher, Burkhard

AU - Samokhvalov, Igor M.

AU - Merad, Miriam

AU - Ginhoux, Florent

PY - 2015/4/21

Y1 - 2015/4/21

N2 - Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth togenerate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fate-mapping of yolk sac (YS) and fetal liver (FL) hematopoiesis. We show that YS MFs are the main precursors of microglia, while most other MFs derive from fetal monocytes (MOs). Both YS MFs and fetal MOs arise from erythro-myeloid progenitors (EMPs) generated in the YS. In the YS, EMPs gave rise to MFs without monocytic intermediates, while EMP seeding the FL upon the establishment of blood circulation acquired c-Myb expression and gave rise to fetal MOs that then seeded embryonic tissues and differentiated into MFs. Thus, adult tissue-resident MFs established from hematopoietic stem cell-independent embryonic precursors arise from two distinct developmental programs.

AB - Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth togenerate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fate-mapping of yolk sac (YS) and fetal liver (FL) hematopoiesis. We show that YS MFs are the main precursors of microglia, while most other MFs derive from fetal monocytes (MOs). Both YS MFs and fetal MOs arise from erythro-myeloid progenitors (EMPs) generated in the YS. In the YS, EMPs gave rise to MFs without monocytic intermediates, while EMP seeding the FL upon the establishment of blood circulation acquired c-Myb expression and gave rise to fetal MOs that then seeded embryonic tissues and differentiated into MFs. Thus, adult tissue-resident MFs established from hematopoietic stem cell-independent embryonic precursors arise from two distinct developmental programs.

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SN - 1074-7613

VL - 42

SP - 665

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JF - Immunity

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