Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus-induced apoptosis

Cynthia Brisac; François Téoulé; Arnaud Autret; Isabelle Pelletier; Florence Colbère-Garapin; Catherine Brenner; Christophe Lemaire; Bruno Blondel

doi:10.1128/JVI.00994-10

Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus-induced apoptosis

Cynthia Brisac, François Téoulé, Arnaud Autret, Isabelle Pelletier, Florence Colbère-Garapin, Catherine Brenner, Christophe Lemaire, Bruno Blondel

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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Résumé

We show that poliovirus (PV) infection induces an increase in cytosolic calcium (Ca²⁺) concentration in neuroblastoma IMR5 cells, at least partly through Ca²⁺ release from the endoplasmic reticulum lumen via the inositol 1,4,5-triphosphate receptor (IP₃R) and ryanodine receptor (RyR) channels. This leads to Ca²⁺ accumulation in mitochondria through the mitochondrial Ca²⁺ uniporter and the voltage-dependent anion channel (VDAC). This increase in mitochondrial Ca ²⁺ concentration in PV-infected cells leads to mitochondrial dysfunction and apoptosis.

langue originale	Anglais
Pages (de - à)	12226-12235
Nombre de pages	10
journal	Journal of Virology
Volume	84
Numéro de publication	23
Les DOIs	https://doi.org/10.1128/JVI.00994-10
état	Publié - 1 déc. 2010
Modification externe	Oui

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10.1128/JVI.00994-10

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title = "Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus-induced apoptosis",

abstract = "We show that poliovirus (PV) infection induces an increase in cytosolic calcium (Ca2+) concentration in neuroblastoma IMR5 cells, at least partly through Ca2+ release from the endoplasmic reticulum lumen via the inositol 1,4,5-triphosphate receptor (IP3R) and ryanodine receptor (RyR) channels. This leads to Ca2+ accumulation in mitochondria through the mitochondrial Ca2+ uniporter and the voltage-dependent anion channel (VDAC). This increase in mitochondrial Ca 2+ concentration in PV-infected cells leads to mitochondrial dysfunction and apoptosis.",

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T1 - Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus-induced apoptosis

AU - Brisac, Cynthia

AU - Téoulé, François

AU - Autret, Arnaud

AU - Pelletier, Isabelle

AU - Colbère-Garapin, Florence

AU - Brenner, Catherine

AU - Lemaire, Christophe

AU - Blondel, Bruno

PY - 2010/12/1

Y1 - 2010/12/1

N2 - We show that poliovirus (PV) infection induces an increase in cytosolic calcium (Ca2+) concentration in neuroblastoma IMR5 cells, at least partly through Ca2+ release from the endoplasmic reticulum lumen via the inositol 1,4,5-triphosphate receptor (IP3R) and ryanodine receptor (RyR) channels. This leads to Ca2+ accumulation in mitochondria through the mitochondrial Ca2+ uniporter and the voltage-dependent anion channel (VDAC). This increase in mitochondrial Ca 2+ concentration in PV-infected cells leads to mitochondrial dysfunction and apoptosis.

AB - We show that poliovirus (PV) infection induces an increase in cytosolic calcium (Ca2+) concentration in neuroblastoma IMR5 cells, at least partly through Ca2+ release from the endoplasmic reticulum lumen via the inositol 1,4,5-triphosphate receptor (IP3R) and ryanodine receptor (RyR) channels. This leads to Ca2+ accumulation in mitochondria through the mitochondrial Ca2+ uniporter and the voltage-dependent anion channel (VDAC). This increase in mitochondrial Ca 2+ concentration in PV-infected cells leads to mitochondrial dysfunction and apoptosis.

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JO - Journal of Virology

JF - Journal of Virology

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