Résumé
The increase in life expectancy has boosted the incidence of age-related pathologies beyond social and economic sustainability. Consequently, there is an urgent need for interventions that revert or at least prevent the pathogenic age-associated deterioration. The permanent or periodic reduction of calorie intake without malnutrition (caloric restriction and fasting) is the only strategy that reliably extends healthspan in mammals including non-human primates. However, the strict and life-long compliance with these regimens is difficult, which has promoted the emergence of caloric restriction mimetics (CRMs). We define CRMs as compounds that ignite the protective pathways of caloric restriction by promoting autophagy, a cytoplasmic recycling mechanism, via a reduction in protein acetylation. Here, we describe the current knowledge on molecular, cellular, and organismal effects of known and putative CRMs in mice and humans. We anticipate that CRMs will become part of the pharmacological armamentarium against aging and age-related cardiovascular, neurodegenerative, and malignant diseases. Madeo et al. summarize the current knowledge on the health-promoting potential of caloric restriction mimetics as a pharmacological option to ignite anti-aging effects. The authors thereby provide mechanistic details for each compound and evaluate the most recent literature on diverse models and clinical trials.
langue originale | Anglais |
---|---|
Pages (de - à) | 592-610 |
Nombre de pages | 19 |
journal | Cell Metabolism |
Volume | 29 |
Numéro de publication | 3 |
Les DOIs | |
état | Publié - 5 mars 2019 |