Calreticulin exposure orchestrates innate immunosurveillance

Emma Guilbaud; Guido Kroemer; Lorenzo Galluzzi

doi:10.1016/j.ccell.2023.04.015

Calreticulin exposure orchestrates innate immunosurveillance

Emma Guilbaud, Guido Kroemer, Lorenzo Galluzzi

Résultats de recherche: Contribution à un journal › !!Comment/debate

10 Citations (Scopus)

Résumé

Calreticulin (CALR) exposure on the cell surface is known to deliver robust pro-phagocytic signals to myeloid cells. In Nature, Sen Santara et al. demonstrate that surface-exposed CALR also operates as an endogenous activator of natural killer (NK) cells. Collectively, these findings suggest that CALR exposure orchestrates multiple facets of innate immunosurveillance.

langue originale	Anglais
Pages (de - à)	1014-1016
Nombre de pages	3
journal	Cancer Cell
Volume	41
Numéro de publication	6
Les DOIs	https://doi.org/10.1016/j.ccell.2023.04.015
état	Publié - 12 juin 2023

Accès au document

10.1016/j.ccell.2023.04.015

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title = "Calreticulin exposure orchestrates innate immunosurveillance",

abstract = "Calreticulin (CALR) exposure on the cell surface is known to deliver robust pro-phagocytic signals to myeloid cells. In Nature, Sen Santara et al. demonstrate that surface-exposed CALR also operates as an endogenous activator of natural killer (NK) cells. Collectively, these findings suggest that CALR exposure orchestrates multiple facets of innate immunosurveillance.",

author = "Emma Guilbaud and Guido Kroemer and Lorenzo Galluzzi",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

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AU - Guilbaud, Emma

AU - Kroemer, Guido

AU - Galluzzi, Lorenzo

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N2 - Calreticulin (CALR) exposure on the cell surface is known to deliver robust pro-phagocytic signals to myeloid cells. In Nature, Sen Santara et al. demonstrate that surface-exposed CALR also operates as an endogenous activator of natural killer (NK) cells. Collectively, these findings suggest that CALR exposure orchestrates multiple facets of innate immunosurveillance.

AB - Calreticulin (CALR) exposure on the cell surface is known to deliver robust pro-phagocytic signals to myeloid cells. In Nature, Sen Santara et al. demonstrate that surface-exposed CALR also operates as an endogenous activator of natural killer (NK) cells. Collectively, these findings suggest that CALR exposure orchestrates multiple facets of innate immunosurveillance.

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DO - 10.1016/j.ccell.2023.04.015

M3 - Comment/debate

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AN - SCOPUS:85161073877

SN - 1535-6108

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JO - Cancer Cell

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