Calreticulin surface presentation can promote quality control of hematopoietic stem cells

Lorenzo Galluzzi; Guido Kroemer

doi:10.1016/j.it.2022.10.008

Calreticulin surface presentation can promote quality control of hematopoietic stem cells

Lorenzo Galluzzi, Guido Kroemer

Résultats de recherche: Contribution à un journal › Brève enquête › Revue par des pairs

1 Citation (Scopus)

Résumé

Endoplasmic reticulum stress can stimulate calreticulin (CALR) presentation on the cell surface, promoting the phagocytic uptake of stressed cells by myeloid cells. Recent findings from Wattrus et al. demonstrate that zebrafish and mouse embryonic macrophages engulf CALR-exposing nascent hematopoietic stem cells to ensure the selective survival of stem cells apt for adult hematopoiesis.

langue originale	Anglais
Pages (de - à)	950-952
Nombre de pages	3
journal	Trends in Immunology
Volume	43
Numéro de publication	12
Les DOIs	https://doi.org/10.1016/j.it.2022.10.008
état	Publié - 1 déc. 2022

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10.1016/j.it.2022.10.008

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abstract = "Endoplasmic reticulum stress can stimulate calreticulin (CALR) presentation on the cell surface, promoting the phagocytic uptake of stressed cells by myeloid cells. Recent findings from Wattrus et al. demonstrate that zebrafish and mouse embryonic macrophages engulf CALR-exposing nascent hematopoietic stem cells to ensure the selective survival of stem cells apt for adult hematopoiesis.",

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