Cancer-Induced Endoplasmic Reticulum Stress in T Cells Subverts Immunosurveillance

Alejandro López-Soto; Guido Kroemer

doi:10.1016/j.cmet.2018.11.003

Cancer-Induced Endoplasmic Reticulum Stress in T Cells Subverts Immunosurveillance

Alejandro López-Soto, Guido Kroemer

Résultats de recherche: Contribution à un journal › Brève enquête › Revue par des pairs

4 Citations (Scopus)

Résumé

Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling within CD4⁺ T lymphocytes, thereby disrupting their bioenergetic function and contribution to anticancer immune responses. Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling within CD4⁺ T lymphocytes, thereby disrupting their bioenergetic function and contribution to anticancer immune responses.

langue originale	Anglais
Pages (de - à)	803-805
Nombre de pages	3
journal	Cell Metabolism
Volume	28
Numéro de publication	6
Les DOIs	https://doi.org/10.1016/j.cmet.2018.11.003
état	Publié - 4 déc. 2018

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10.1016/j.cmet.2018.11.003

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title = "Cancer-Induced Endoplasmic Reticulum Stress in T Cells Subverts Immunosurveillance",

abstract = "Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling within CD4+ T lymphocytes, thereby disrupting their bioenergetic function and contribution to anticancer immune responses. Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling within CD4+ T lymphocytes, thereby disrupting their bioenergetic function and contribution to anticancer immune responses.",

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