Cancer-testis antigen fate1 expression in adrenocortical tumors is associated with a pervasive autoimmune response and is a marker of malignancy in adult, but not children, acc

Mabrouka Doghman-Bouguerra; Pascal Finetti; Nelly Durand; Ivy Zortéa S. Parise; Silviu Sbiera; Giulia Cantini; Letizia Canu; Ségolène Hescot; Mirna M.O. Figueiredo; Heloisa Komechen; Iuliu Sbiera; Gabriella Nesi; Angelo Paci; Abir Al Ghuzlan; Daniel Birnbaum; Eric Baudin; Michaela Luconi; Martin Fassnacht; Bonald C. Figueiredo; François Bertucci; Enzo Lalli

doi:10.3390/cancers12030689

Cancer-testis antigen fate1 expression in adrenocortical tumors is associated with a pervasive autoimmune response and is a marker of malignancy in adult, but not children, acc

Mabrouka Doghman-Bouguerra, Pascal Finetti, Nelly Durand, Ivy Zortéa S. Parise, Silviu Sbiera, Giulia Cantini, Letizia Canu, Ségolène Hescot, Mirna M.O. Figueiredo, Heloisa Komechen, Iuliu Sbiera, Gabriella Nesi, Angelo Paci, Abir Al Ghuzlan, Daniel Birnbaum, Eric Baudin, Michaela Luconi, Martin Fassnacht, Bonald C. Figueiredo, François BertucciEnzo Lalli

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

14 Citations (Scopus)

Résumé

The SF-1 transcription factor target gene FATE1 encodes a cancer-testis antigen that has an important role in regulating apoptosis and response to chemotherapy in adrenocortical carcinoma (ACC) cells. Autoantibodies directed against FATE1 were previously detected in patients with hepatocellular carcinoma. In this study, we investigated the prevalence of circulating anti-FATE1 antibodies in pediatric and adult patients with adrenocortical tumors using three different methods (immunofluorescence, ELISA and Western blot). Our results show that a pervasive anti-FATE1 immune response is present in those patients. Furthermore, FATE1 expression is a robust prognostic indicator in adult patients with ACC and is associated with increased steroidogenic and decreased immune response gene expression. These data can open perspectives for novel strategies in ACC immunotherapy.

langue originale	Anglais
Numéro d'article	689
journal	Cancers
Volume	12
Numéro de publication	3
Les DOIs	https://doi.org/10.3390/cancers12030689
état	Publié - 1 mars 2020

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10.3390/cancers12030689

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Doghman-Bouguerra, M., Finetti, P., Durand, N., Parise, I. Z. S., Sbiera, S., Cantini, G., Canu, L., Hescot, S., Figueiredo, M. M. O., Komechen, H., Sbiera, I., Nesi, G., Paci, A., Al Ghuzlan, A., Birnbaum, D., Baudin, E., Luconi, M., Fassnacht, M., Figueiredo, B. C., ... Lalli, E. (2020). Cancer-testis antigen fate1 expression in adrenocortical tumors is associated with a pervasive autoimmune response and is a marker of malignancy in adult, but not children, acc. Cancers, 12(3), Article 689. https://doi.org/10.3390/cancers12030689

@article{282ef882b74a4700b607f435ebe730b5,

title = "Cancer-testis antigen fate1 expression in adrenocortical tumors is associated with a pervasive autoimmune response and is a marker of malignancy in adult, but not children, acc",

abstract = "The SF-1 transcription factor target gene FATE1 encodes a cancer-testis antigen that has an important role in regulating apoptosis and response to chemotherapy in adrenocortical carcinoma (ACC) cells. Autoantibodies directed against FATE1 were previously detected in patients with hepatocellular carcinoma. In this study, we investigated the prevalence of circulating anti-FATE1 antibodies in pediatric and adult patients with adrenocortical tumors using three different methods (immunofluorescence, ELISA and Western blot). Our results show that a pervasive anti-FATE1 immune response is present in those patients. Furthermore, FATE1 expression is a robust prognostic indicator in adult patients with ACC and is associated with increased steroidogenic and decreased immune response gene expression. These data can open perspectives for novel strategies in ACC immunotherapy.",

keywords = "Adrenocortical carcinoma, Autoantibodies, Cancer-testis antigens, Immune response",

author = "Mabrouka Doghman-Bouguerra and Pascal Finetti and Nelly Durand and Parise, {Ivy Zort{\'e}a S.} and Silviu Sbiera and Giulia Cantini and Letizia Canu and S{\'e}gol{\`e}ne Hescot and Figueiredo, {Mirna M.O.} and Heloisa Komechen and Iuliu Sbiera and Gabriella Nesi and Angelo Paci and {Al Ghuzlan}, Abir and Daniel Birnbaum and Eric Baudin and Michaela Luconi and Martin Fassnacht and Figueiredo, {Bonald C.} and Fran{\c c}ois Bertucci and Enzo Lalli",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = mar,

day = "1",

doi = "10.3390/cancers12030689",

language = "English",

volume = "12",

journal = "Cancers",

issn = "2072-6694",

number = "3",

}

Doghman-Bouguerra, M, Finetti, P, Durand, N, Parise, IZS, Sbiera, S, Cantini, G, Canu, L, Hescot, S, Figueiredo, MMO, Komechen, H, Sbiera, I, Nesi, G, Paci, A, Al Ghuzlan, A, Birnbaum, D, Baudin, E, Luconi, M, Fassnacht, M, Figueiredo, BC, Bertucci, F & Lalli, E 2020, 'Cancer-testis antigen fate1 expression in adrenocortical tumors is associated with a pervasive autoimmune response and is a marker of malignancy in adult, but not children, acc', Cancers, VOL. 12, Numéro 3, 689. https://doi.org/10.3390/cancers12030689

Cancer-testis antigen fate1 expression in adrenocortical tumors is associated with a pervasive autoimmune response and is a marker of malignancy in adult, but not children, acc. / Doghman-Bouguerra, Mabrouka; Finetti, Pascal; Durand, Nelly et al.
Dans: Cancers, Vol 12, Numéro 3, 689, 01.03.2020.

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

TY - JOUR

T1 - Cancer-testis antigen fate1 expression in adrenocortical tumors is associated with a pervasive autoimmune response and is a marker of malignancy in adult, but not children, acc

AU - Doghman-Bouguerra, Mabrouka

AU - Finetti, Pascal

AU - Durand, Nelly

AU - Parise, Ivy Zortéa S.

AU - Sbiera, Silviu

AU - Cantini, Giulia

AU - Canu, Letizia

AU - Hescot, Ségolène

AU - Figueiredo, Mirna M.O.

AU - Komechen, Heloisa

AU - Sbiera, Iuliu

AU - Nesi, Gabriella

AU - Paci, Angelo

AU - Al Ghuzlan, Abir

AU - Birnbaum, Daniel

AU - Baudin, Eric

AU - Luconi, Michaela

AU - Fassnacht, Martin

AU - Figueiredo, Bonald C.

AU - Bertucci, François

AU - Lalli, Enzo

PY - 2020/3/1

Y1 - 2020/3/1

N2 - The SF-1 transcription factor target gene FATE1 encodes a cancer-testis antigen that has an important role in regulating apoptosis and response to chemotherapy in adrenocortical carcinoma (ACC) cells. Autoantibodies directed against FATE1 were previously detected in patients with hepatocellular carcinoma. In this study, we investigated the prevalence of circulating anti-FATE1 antibodies in pediatric and adult patients with adrenocortical tumors using three different methods (immunofluorescence, ELISA and Western blot). Our results show that a pervasive anti-FATE1 immune response is present in those patients. Furthermore, FATE1 expression is a robust prognostic indicator in adult patients with ACC and is associated with increased steroidogenic and decreased immune response gene expression. These data can open perspectives for novel strategies in ACC immunotherapy.

AB - The SF-1 transcription factor target gene FATE1 encodes a cancer-testis antigen that has an important role in regulating apoptosis and response to chemotherapy in adrenocortical carcinoma (ACC) cells. Autoantibodies directed against FATE1 were previously detected in patients with hepatocellular carcinoma. In this study, we investigated the prevalence of circulating anti-FATE1 antibodies in pediatric and adult patients with adrenocortical tumors using three different methods (immunofluorescence, ELISA and Western blot). Our results show that a pervasive anti-FATE1 immune response is present in those patients. Furthermore, FATE1 expression is a robust prognostic indicator in adult patients with ACC and is associated with increased steroidogenic and decreased immune response gene expression. These data can open perspectives for novel strategies in ACC immunotherapy.

KW - Adrenocortical carcinoma

KW - Autoantibodies

KW - Cancer-testis antigens

KW - Immune response

UR - http://www.scopus.com/inward/record.url?scp=85082414525&partnerID=8YFLogxK

U2 - 10.3390/cancers12030689

DO - 10.3390/cancers12030689

M3 - Article

AN - SCOPUS:85082414525

SN - 2072-6694

VL - 12

JO - Cancers

JF - Cancers

IS - 3

M1 - 689

ER -