Cancers bronchiques des non-fumeurs: particularités épidémiologiques, thérapeutiques et moléculaires

Smoking status is essential to know when taking care of a lung cancer patient.Never-smoking patients account for 15% of lung cancer patients, more often women and adenocarcinoma.Environmental tobacco smoke and occupational exposure could be important risk factors.Lung cancer in never-smoker appears to be a distinct entity from lung cancer in smoker, with specific molecular characteristics such as frequent EGFR mutations.New molecular targets are on investigation, such as EML4-ALK translocation.Treatment of lung cancer in never-smoker is getting different from that of smoker with more efficacy of molecular targeted therapies.