Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker?

Patricia Martin-Romano; Julien Adam; Jean Yves Scoazec; Sébastien Gouy; Antonin Levy; Capucine Baldini; Stéphane Champiat; Jean Charles Soria; Christophe Massard; Aurélien Marabelle; Eric Deutsch; Antoine Hollebecque

doi:10.3389/fimmu.2021.745146

Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker?

Patricia Martin-Romano, Julien Adam, Jean Yves Scoazec, Sébastien Gouy, Antonin Levy, Capucine Baldini, Stéphane Champiat, Jean Charles Soria, Christophe Massard, Aurélien Marabelle, Eric Deutsch, Antoine Hollebecque

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

2 Citations (Scopus)

Résumé

Immunotherapy has dramatically changed the treatment landscape for several tumor types. However, the impact of previous radiotherapy (RT) on response to immunotherapy is still unknown. We report the case of a 58-year-old female diagnosed with a squamous anal cell carcinoma previously treated with RT and having a dissociated response to anti-PD1 agent. An extensive analysis of the immune contexture performed on the tissue collected from both previously RT-treated and RT-untreated lesions confirmed differences on immune microenvironment, highlighting the potential impact of radiotherapy on the immune response.

langue originale	Anglais
Numéro d'article	745146
journal	Frontiers in Immunology
Volume	12
Les DOIs	https://doi.org/10.3389/fimmu.2021.745146
état	Publié - 4 nov. 2021

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10.3389/fimmu.2021.745146

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@article{bc1932b6678c4eb2b9a35dc8a60de24a,

title = "Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker?",

abstract = "Immunotherapy has dramatically changed the treatment landscape for several tumor types. However, the impact of previous radiotherapy (RT) on response to immunotherapy is still unknown. We report the case of a 58-year-old female diagnosed with a squamous anal cell carcinoma previously treated with RT and having a dissociated response to anti-PD1 agent. An extensive analysis of the immune contexture performed on the tissue collected from both previously RT-treated and RT-untreated lesions confirmed differences on immune microenvironment, highlighting the potential impact of radiotherapy on the immune response.",

keywords = "anal squamous cell carcinoma, immune microenvironment, immunotherapy, radiation therapy, tumor response",

author = "Patricia Martin-Romano and Julien Adam and Scoazec, {Jean Yves} and S{\'e}bastien Gouy and Antonin Levy and Capucine Baldini and St{\'e}phane Champiat and Soria, {Jean Charles} and Christophe Massard and Aur{\'e}lien Marabelle and Eric Deutsch and Antoine Hollebecque",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Martin-Romano, Adam, Scoazec, Gouy, Levy, Baldini, Champiat, Soria, Massard, Marabelle, Deutsch and Hollebecque.",

year = "2021",

month = nov,

day = "4",

doi = "10.3389/fimmu.2021.745146",

language = "English",

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AU - Martin-Romano, Patricia

AU - Adam, Julien

AU - Scoazec, Jean Yves

AU - Gouy, Sébastien

AU - Levy, Antonin

AU - Baldini, Capucine

AU - Champiat, Stéphane

AU - Soria, Jean Charles

AU - Massard, Christophe

AU - Marabelle, Aurélien

AU - Deutsch, Eric

AU - Hollebecque, Antoine

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N2 - Immunotherapy has dramatically changed the treatment landscape for several tumor types. However, the impact of previous radiotherapy (RT) on response to immunotherapy is still unknown. We report the case of a 58-year-old female diagnosed with a squamous anal cell carcinoma previously treated with RT and having a dissociated response to anti-PD1 agent. An extensive analysis of the immune contexture performed on the tissue collected from both previously RT-treated and RT-untreated lesions confirmed differences on immune microenvironment, highlighting the potential impact of radiotherapy on the immune response.

AB - Immunotherapy has dramatically changed the treatment landscape for several tumor types. However, the impact of previous radiotherapy (RT) on response to immunotherapy is still unknown. We report the case of a 58-year-old female diagnosed with a squamous anal cell carcinoma previously treated with RT and having a dissociated response to anti-PD1 agent. An extensive analysis of the immune contexture performed on the tissue collected from both previously RT-treated and RT-untreated lesions confirmed differences on immune microenvironment, highlighting the potential impact of radiotherapy on the immune response.

KW - anal squamous cell carcinoma

KW - immune microenvironment

KW - immunotherapy

KW - radiation therapy

KW - tumor response

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