TY - JOUR
T1 - CD10 is expressed in a subset of chromophobe renal cell carcinomas
AU - Martignoni, Guido
AU - Pea, Maurizio
AU - Brunelli, Matteo
AU - Chilosi, Marco
AU - Zamo, Alberto
AU - Bertaso, Manuela
AU - Cossu-Rocca, Paolo
AU - Eble, John N.
AU - Mikuz, Gregor
AU - Puppa, Giacomo
AU - Badoual, Cecile
AU - Ficarra, Vincenzo
AU - Novella, Giovanni
AU - Bonetti, Franco
PY - 2004/12/1
Y1 - 2004/12/1
N2 - CD10 has been considered a useful marker in the diagnosis of renal carcinomas, because of its expression in clear cell and papillary renal cell carcinomas and its absence in chromophobe renal cell carcinomas. On the other hand, chromophobe renal cell carcinoma expresses parvalbumin, which is absent in clear cell and papillary renal cell carcinomas. To further address the relevance of these markers, we studied the expression of CD10 and parvalbumin in 42 samples of chromophobe renal cell carcinoma (seven of which had aggressive features, including invasion beyond the renal capsule, renal vein invasion, metastases, or sarcomatoid transformation), 75 clear cell renal cell carcinomas (eight metastatic) and 51 papillary renal cell carcinomas (two metastatic). CD10 was found in 100% of clear cell renal cell carcinomas, 63% of papillary renal cell carcinomas and in all metastatic cases of both types. At variance with previous studies, we found CD10 expression in from 30 to 90% of the neoplastic cells, in 11 of 42 (26%) chromophobe renal cell carcinomas. The CD10-positive cases included five of the seven (71%) chromophobe renal cell carcinoma with aggressive features. Statistical analysis showed significant association of CD10-positive tumors with clinicopathologic aggressiveness (P= 0.003) and mitotic figures (P= 0.04). Parvalbumin was strongly expressed in all primary and metastatic chromophobe renal cell carcinomas. Western blot analysis was utilized to confirm the expression of both CD10 and parvalbumin in chromophobe renal cell carcinomas.
AB - CD10 has been considered a useful marker in the diagnosis of renal carcinomas, because of its expression in clear cell and papillary renal cell carcinomas and its absence in chromophobe renal cell carcinomas. On the other hand, chromophobe renal cell carcinoma expresses parvalbumin, which is absent in clear cell and papillary renal cell carcinomas. To further address the relevance of these markers, we studied the expression of CD10 and parvalbumin in 42 samples of chromophobe renal cell carcinoma (seven of which had aggressive features, including invasion beyond the renal capsule, renal vein invasion, metastases, or sarcomatoid transformation), 75 clear cell renal cell carcinomas (eight metastatic) and 51 papillary renal cell carcinomas (two metastatic). CD10 was found in 100% of clear cell renal cell carcinomas, 63% of papillary renal cell carcinomas and in all metastatic cases of both types. At variance with previous studies, we found CD10 expression in from 30 to 90% of the neoplastic cells, in 11 of 42 (26%) chromophobe renal cell carcinomas. The CD10-positive cases included five of the seven (71%) chromophobe renal cell carcinoma with aggressive features. Statistical analysis showed significant association of CD10-positive tumors with clinicopathologic aggressiveness (P= 0.003) and mitotic figures (P= 0.04). Parvalbumin was strongly expressed in all primary and metastatic chromophobe renal cell carcinomas. Western blot analysis was utilized to confirm the expression of both CD10 and parvalbumin in chromophobe renal cell carcinomas.
KW - CD10
KW - Chromophobe renal cell carcinoma
KW - Immunohistochemistry
KW - Parvalbumin
KW - Renal cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=10344223981&partnerID=8YFLogxK
U2 - 10.1038/modpathol.3800236
DO - 10.1038/modpathol.3800236
M3 - Article
C2 - 15286660
AN - SCOPUS:10344223981
SN - 0893-3952
VL - 17
SP - 1455
EP - 1463
JO - Modern Pathology
JF - Modern Pathology
IS - 12
ER -