TY - JOUR
T1 - CD11b+ DCs rediscovered
T2 - Implications for vaccination
AU - Ginhoux, Florent
AU - Schlitzer, Andreas
N1 - Funding Information:
This work was supported by the Singapore Immunology Network core grant. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Dendritic cells (DCs) are potent antigen sensing and presenting cells, able to both initiate and orchestrate complex immune responses. DCs are optimally equipped to recognize pathogens, as well as self-antigens and vaccine components, and instruct the type, magnitude and specificity of the ensuing immunity. However, the DC population is remarkably heterogeneous and consists of multiple subsets with different ontogeny, differentiation and functional specializations. Therefore, a deeper understanding of DC subset biology is fundamental for the development and implementation of innovative vaccination strategies.
AB - Dendritic cells (DCs) are potent antigen sensing and presenting cells, able to both initiate and orchestrate complex immune responses. DCs are optimally equipped to recognize pathogens, as well as self-antigens and vaccine components, and instruct the type, magnitude and specificity of the ensuing immunity. However, the DC population is remarkably heterogeneous and consists of multiple subsets with different ontogeny, differentiation and functional specializations. Therefore, a deeper understanding of DC subset biology is fundamental for the development and implementation of innovative vaccination strategies.
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=84896475260&partnerID=8YFLogxK
U2 - 10.1586/14760584.2014.893196
DO - 10.1586/14760584.2014.893196
M3 - Review article
C2 - 24564769
AN - SCOPUS:84896475260
SN - 1476-0584
VL - 13
SP - 445
EP - 447
JO - Expert Review of Vaccines
JF - Expert Review of Vaccines
IS - 4
ER -